Ro 3280

Key Product Details

Product Description

Ro 3280 is a potent and selective PLK inhibitor (IC₅₀ = 3 nM). Exhibits selectivity for PLK1 over a panel of other kinases. Inhibits growth of a range of tumor cells lines in vitro and induces apoptosis in leukemia cells. Exhibits antitumor activity in mouse colorectal and nasopharyngeal cancer models in vivo.

Product Specifications for Ro 3280

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Ro 3280

The following data is based on the product molecular weight 543.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.68 mL	18.40 mL	36.79 mL
2.5 mM	0.74 mL	3.68 mL	7.36 mL
5 mM	0.37 mL	1.84 mL	3.68 mL
25 mM	0.07 mL	0.37 mL	0.74 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Chen Identification of novel, potent and selective inhibitors of Polo-like kinase 1. Bioorg.Med.Chem.Lett. 2012 PMID: 22172702
• Wang Molecular targeting of the oncoprotein PLK1 in pediatric acute myeloid leukemia: RO3280, a novel PLK1 inhibitor, induces apoptosis in leukemia cells. Int.J.Mol.Sci. 2015 PMID: 25574601
• Cheung Polo-like kinase inhibitor Ro5203280 has potent antitumor activity in nasopharyngeal carcinoma. Mol.Cancer Ther. 2013 PMID: 23686835

Product Documents for Ro 3280