Ro 5-3335

Catalog # Availability Size / Price Qty
4694/10
Cat.No. 4694 - Ro 5-3335 | C13H10ClN3O | CAS No. 30195-30-3
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Description: Core binding factor inhibitor; attenuates hematopoiesis
Alternative Names: CBFβ-Runx1 inhibitor II

Chemical Name: 7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Reduces leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. Also a Tat antagonist; inhibits HIV-1 replication in vitro.

Technical Data

M.Wt:
259.69
Formula:
C13H10ClN3O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
30195-30-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Ro 5-3335

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