Chemical Name: 7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one
Biological ActivityCore binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Reduces leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. Also a Tat antagonist; inhibits HIV-1 replication in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The human immunodeficiency virus type 1 Tat antagonist, Ro 5-3335, predominantly inhibits transcription initiation from the viral promoter.
Cupelli et al.
Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBF� interaction.
Cunningham et al.
RUNX1/AML1: a central player in hematopoiesis.
Okuda et al.
Int. J. Hematol., 2001;74:252
Citation for Ro 5-3335
The citations listed below are publications that use Tocris products. Selected citations for Ro 5-3335 include:
1 Citation: Showing 1 - 1
Runt-related Transcription Factor 1 (RUNX1) Binds to p50 in Macrophages and Enhances TLR4-triggeredInflammation and Septic Shock.
Authors: Luo Et al.
Journal of Biological Chemistry 2016;
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