Catalog Number: 3896
Alternate Names: N 0923
Chemical Name: (6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol hydrochloride
Biological Activity
Dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Also has significant affinity for 5-HT1A and adrenergic α2B receptors. Exhibits antiparkinsonian acitivity.
Technical Data
  • M.Wt:
    351.93
  • Formula:
    C19H25NOS.HCl
  • Solubility:
    Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    125572-93-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease.
    Scheller et al.
    Naunyn.Schmiedebergs.Arch.Pharmacol., 2009;379:73
  2. N-0923, a selective dopamine D2 receptor agonist, is efficacious in rat and monkey models of Parkinson's disease.
    Belluzzi et al.
    Mov.Disord., 2004;9:147
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Rotigotine hydrochloride include:

1 Citations: Showing 1 - 1

  1. Dopamine D(2) receptor-mediated modulation of adenosine A(2A) receptor agonist binding within the A(2A)R/D(2)R oligomer framework.
    Authors: Fernández-Dueñas Et al.
    J Exp Clin Cancer Res 2013;63:42

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