Chemical Name: (6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol hydrochloride
Biological ActivityRotigotine hydrochloride is a dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Also has significant affinity for 5-HT1A and adrenergic α2B receptors. Exhibits antiparkinsonian acitivity.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease.
Scheller et al.
N-0923, a selective DA D2 receptor agonist, is efficacious in rat and monkey models of Parkinson's disease.
Belluzzi et al.
Citation for Rotigotine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Rotigotine hydrochloride include:
1 Citation: Showing 1 - 1
DA D(2) receptor-mediated modulation of adenosine A(2A) receptor agonist binding within the A(2A)R/D(2)R oligomer framework.
Authors: Fernández-Dueñas Et al.
J Exp Clin Cancer Res 2013;63:42
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