RS 17053 hydrochloride

Key Product Details

Product Description

RS 17053 hydrochloride is an α_1A-adrenoceptor antagonist, with very high affinity for α_1A receptors (pK_i and pA₂ estimates of 9.1 - 9.9) and a 30 - 100 fold selectivity over the α_1B and α_1D subtypes (pK_i and pA₂ estimates 7.7 - 7.8).

Licensing Information

Sold with the permission of Roche Bioscience

Product Specifications for RS 17053 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for RS 17053 hydrochloride

The following data is based on the product molecular weight 449.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.45 mL	22.25 mL	44.50 mL
2.5 mM	0.89 mL	4.45 mL	8.90 mL
5 mM	0.45 mL	2.23 mL	4.45 mL
25 mM	0.09 mL	0.45 mL	0.89 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• Marshall Different subtypes of α_1A-adrenoceptor mediating contraction of rat epididymal vas deferens, rat hepatic portal vein and human prostate distinguished by the antagonist RS 17053. Br.J.Pharmacol. 1996 PMID: 8886428
• Ford Do α_1A (α_1C)-adrenoceptors (AR) mediate prostatic smooth muscle contraction in man? Studies with a novel, selective α_1A-AR antagonist, RS 17053. Br.J.Pharmacol.
• Ford RS 17053 (N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-α,α-dimethyl-1H-indole-3-ethanamine hydrochloride, a selective α1A-adrenoceptor antagonist, displays low affinity for functional α1-adrenoceptors in huma Mol.Pharmacol. 1996 PMID: 8632751

Product Documents for RS 17053 hydrochloride