Catalog Number: 0342
Chemical Name: (RS)-3,5-Dihydroxyphenylglycine
Biological Activity
Selective group I metabotropic glutamate receptor agonist which activates both mGlu1 and mGlu5. Also reported to be an antagonist at metabotropic glutamate receptors linked to phospholipase D. (S)-3,5-DHPG (Cat. No. 0805) also available.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in water
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. 3,5-Dihydroxyphenylglycine: a potent agonist of metabotropic glutamate receptors.
    Ito et al.
    NeuroReport, 1992;3:1013
  2. Regulation of phosphoinositide turnover in neonatal rat cerebral cortex by group I- and II-selective metabotropic glutamate receptor agonists.
    Mistry et al.
    Br.J.Pharmacol., 1998;123:581
  3. The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus.
    Palmer et al.
    Neuropharmacology, 1997;36:1517
  4. Pharmacological characterization of metabotropic glutamate recpetors coupled to phopholipase D in the rat hippocampus.
    Pellegrini-Giampietro et al.
    Br.J.Pharmacol., 1996;118:1035

The citations listed below are publications that use Tocris products. Selected citations for (RS)-3,5-DHPG include:

Showing Results 1 - 10 of 37

  1. Colocalization�of�neurotransmitter�transporters�on the�plasma�membrane�of the�same�nerve�terminal�may reflect�cotransmission.
    Authors: Romei Et al.
    Brain Research Bulletin
  2. Dendritic spine dynamics leading to spine elimination after repeated inductions of LTD.
    Authors: Hasegawa Et al.
    J Neurosci
  3. BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain dopamine neurons.
    Authors: Zhong Et al.
    Sci Rep
  4. PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome.
    Authors: Choi Et al.
    Proc Natl Acad Sci U S A
  5. Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices.
    Authors: Takano Et al.
  6. Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase.
    Authors: Lee Et al.
    Philos Trans R Soc Lond B Biol Sci
  7. Involvement of TrkB- and p75(NTR)-signaling pathways in two contrasting forms of long-lasting synaptic plasticity.
    Authors: Sakuragi Et al.
    J Vis Exp
  8. Modulation of mGluR-dependent MAP1B translation and AMPA receptor endocytosis by microRNA miR-146a-5p.
    Authors: Chen and Shen
    J Neurosci
  9. Simultaneous monitoring of presynaptic transmitter release and postsynaptic receptor trafficking reveals an enhancement of presynaptic activity in metabotropic glutamate receptor-mediated long-term depression.
    Authors: Xu Et al.
    J Neurosci
  10. Impaired activity-dependent FMRP translation and enhanced mGluR-dependent LTD in Fragile X premutation mice.
    Authors: Iliff Et al.
    Hum Mol Genet
  11. The plasma membrane Ca2+-ATPase2 (PMCA2) is involved in the regulation of Purkinje cell dendritic growth in cerebellar organotypic slice cultures.
    Authors: Sherkhane and Kapfhammer
    J Neurosci
  12. The analysis of purkinje cell dendritic morphology in organotypic slice cultures.
    Authors: Kapfhammer and Gugger
    J Neurosci
  13. Central amygdala metabotropic glutamate receptor 5 in the modulation of visceral pain.
    Authors: Crock Et al.
    Eur J Neurosci
  14. MeCP2 phosphorylation is required for modulating synaptic scaling through mGluR5.
    Authors: Zhong Et al.
    Stem Cell Reports
  15. Activity Modes in Thalamocortical Relay Neurons are Modulated by G(q)/G(11) Family G-proteins - Serotonergic and Glutamatergic Signaling.
    Authors: Coulon Et al.
    Front Cell Neurosci
  16. Loss of Tsc1 in vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic function.
    Authors: Bateup Et al.
    Neurosci Lett
  17. Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry.
    Authors: Hays Et al.
    J Neurosci
  18. Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior.
    Authors: Kolber Et al.
    Sci Rep
  19. Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(β)42 from isolated intact nerve terminals.
    Authors: Kim Et al.
    J Neurosci
  20. Neuroligin 1 is dynamically exchanged at postsynaptic sites.
    Authors: Schapitz Et al.
    J Neurosci
  21. Converging signal on ERK1/2 activity regulates group I mGluR-mediated Arc transcription.
    Authors: Wang Et al.
    J Neurosci
  22. N-methyl-D-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system.
    Authors: Citri Et al.
    J Neurosci
  23. Fast subplasma membrane Ca2+ transients control exo-endocytosis of synaptic-like microvesicles in astrocytes.
    Authors: Marchaland Et al.
    J Neurosci
  24. The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation.
    Authors: Zhang Et al.
    J Neurosci
  25. Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome.
    Authors: Kim Et al.
    J Neurosci
  26. Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome.
    Authors: Muddashetty Et al.
    J Neurosci
  27. Disynaptic amplification of metabotropic glutamate receptor 1 responses in the olfactory bulb.
    Authors: Jan and Westbrook
    J Neurosci
  28. Vesicular release of glutamate from unmyelinated axons in white matter.
    Authors: Ziskin Et al.
    Proc Natl Acad Sci U S A
  29. A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context.
    Authors: Etkin Et al.
  30. Visual experience regulates metabotropic glutamate receptor-mediated plasticity of AMPA receptor synaptic transmission by homer1a induction.
    Authors: Keuren-Jensen and Cline
    J Neurosci
  31. Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum.
    Authors: Rancillac Et al.
    J Neurosci
  32. Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.
    Authors: Calò Et al.
    J Neurosci
  33. Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1.
    Authors: Gallagher Et al.
    Neural Plast
  34. Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling.
    Authors: Nishi Et al.
    J Neurosci
  35. Altered synaptic plasticity in a mouse model of fragile X mental retardation.
    Authors: Huber Et al.
    Proc Natl Acad Sci U S A
  36. Neutrophil-derived glutamate regulates vascular endothelial barrier function.
    Authors: Collard Et al.
    J Biol Chem
  37. Identification of sites for exponential translation in living dendrites.
    Authors: Job and Eberwine
    Proc Natl Acad Sci U S A
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