Potent neuropeptide Y (NPY) Y5
receptor antagonist (IC50
values are 5.4, > 1000, > 10 000 and > 10 000 nM at Y5
receptors respectively) that displays no affinity for a wide range of other receptors. Does not produce a conditioned taste aversion, suppress sodium appetite or cause pica in rats. Significantly inhibits NPY-induced feeding but not through blockade of Y5
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Functional characterization of human neuropeptide Y receptor subtype 5 specific antagonists using a luciferase reporter gene assay.
Beauverger et al.
A potent and selective NPY Y5 antagonist reduces food intake but not through blockade of the NPY Y5 receptor.
Della-Zuana et al.