S 25585

Catalog # Availability Size / Price Qty
3432/10
3432/50
S 25585 | CAS No. 263849-50-9 | NPY Receptor Antagonists
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Description: Potent and selective NPY Y5 receptor antagonist

Chemical Name: 1-Benzoyl-2-[[trans-4-[[[[2-nitro-4-(trifluoromethyl)phenyl]sulfonyl]amino]methyl]cyclohexyl]carbonyl]hydrazine

Purity: ≥98%

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Biological Activity

Potent neuropeptide Y (NPY) Y5 receptor antagonist (IC50 values are 5.4, > 1000, > 10 000 and > 10 000 nM at Y5, Y1, Y2 and Y4 receptors respectively) that displays no affinity for a wide range of other receptors. Does not produce a conditioned taste aversion, suppress sodium appetite or cause pica in rats. Significantly inhibits NPY-induced feeding but not through blockade of Y5 receptors.

Technical Data

M.Wt:
528.5
Formula:
C22H23F3N4O6S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
263849-50-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Functional characterization of human neuropeptide Y receptor subtype 5 specific antagonists using a luciferase reporter gene assay.
    Beauverger et al.
    Cell.Signal., 2005;17:489
  2. A potent and selective NPY Y5 antagonist reduces food intake but not through blockade of the NPY Y5 receptor.
    Della-Zuana et al.
    Int.J.Obes., 2004;28:628

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