SAHA

Catalog # Availability Size / Price Qty
4652/10
4652/50
SAHA | CAS No. 149647-78-9 | Class I Histone Deacetylases Inhibitors
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Description: Class I and II HDAC inhibitor
Alternative Names: Vorinostat

Chemical Name: N-Hydroxy-N'-phenyloctanediamide

Purity: ≥98%

Product Details
Citations (3)
Reviews

Biological Activity

SAHA inhibits Class I and II histone deacetylases (HDACs); induces accumulation of acetylated histones H2A, H2B, H3 and H4 in transformed cultured cells. Suppresses cell growth in a range of cancer cell lines; induces apoptosis in cutaneous T cell lymphoma cells in vitro. Activates autophagy. SAHA increases efficiency of transcription factor-induced reprogramming of mouse embryonic fibroblasts (MEF) to induced pluripotent stem cells (iPSC). Also enhances adeno-associated virus transduction of HeLa cells.

Technical Data

M.Wt:
264.32
Formula:
C14H20N2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
149647-78-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SAHA

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