Chemical Name: N-Hydroxy-N'-phenyloctanediamide
Biological ActivitySAHA inhibits Class I and II histone deacetylases (HDACs); induces accumulation of acetylated histones H2A, H2B, H3 and H4 in transformed cultured cells. Suppresses cell growth in a range of cancer cell lines; induces apoptosis in cutaneous T cell lymphoma cells in vitro. Activates autophagy. SAHA increases efficiency of transcription factor-induced reprogramming of mouse embryonic fibroblasts (MEF) to induced pluripotent stem cells (iPSC). Also enhances adeno-associated virus transduction of HeLa cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines.
Leoni et al.
Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug.
Marks and Breslow
Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds.
Huangfu et al.
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
Galluzzi et al.
Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo.
Butler et al.
Cancer Res., 2000;60:5165
Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens.
Nicolson et al.
Citations for SAHA
The citations listed below are publications that use Tocris products. Selected citations for SAHA include:
8 Citations: Showing 1 - 8
INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury.
Authors: Steven L Et al.
Nat Commun 2022;13:6037
Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes.
Authors: Jacques Et al.
ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation.
Authors: Asgerally T Et al.
Cell Rep 2020;33:108366
Celecoxib Prevents Doxorubicin-Induced Multidrug Resistance in Canine and Mouse Lymphoma Cell Lines.
Authors: Gergely Et al.
Cancers (Basel) 2020;12
Compounds targeting class II histone deacetylases do not cause panHDACI-associated impairment of megakaryocyte differentiation.
Authors: Nianli Et al.
Exp Hematol 2019;72:36-46
Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation.
Authors: Ng-Blichfeldt Et al.
RAD51 interconnects between DNA replication, DNA repair and immunity.
Authors: Bhattacharya Et al.
Nucleic Acids Res 2017;45:4590
Single-cell analysis reveals IGF-1 potentiation of inhibition of the TGF-β/Smad pathway of fibrosis in humankeratocytes in vitro
Authors: Sarenac Et al.
Scientific Reports 2016;6:34373
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