Catalog Number: 1175
Biological Activity
Highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Disulfide bridge between 1 - 15, 3 - 11)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Distinct endothelin-B receptors mediate the effects of sarafotoxin S6c and IRL 1620 in the ileum.
    Miasiro et al.
    J.Cardiovasc.Pharmacol., 1998;31:S175
  2. Effects of sarafotoxin S6c on antidiuresis and norepinephrine overflow induced by stimulation of renal nerves in anesthetized dogs.
    Matsuo et al.
    J.Pharmacol.Exp.Ther., 1997;280:905
  3. Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes.
    Williams et al.
    Biochem.Biophys.Res.Commun., 1991;175:556
  4. Characterization of cloned human endothelin receptors.
    Williams et al.
    Life Sci., 1993;53:407

The citations listed below are publications that use Tocris products. Selected citations for Sarafotoxin S6c include:

1 Citations: Showing 1 - 1

  1. Functional and molecular characterization of the endothelin system in retinal arterioles.
    Authors: Hein Et al.
    Br J Pharmacol 2009;50:3329

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