SB 399885 hydrochloride

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SB 399885 hydrochloride | CAS No. 402713-81-9 | 5-HT6 Receptor Antagonists
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Description: Potent and selective 5-HT6 antagonist

Chemical Name: N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamide hydrochloride

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

Potent, brain penetrant, orally active 5-HT6 antagonist. Displays > 200-fold selectivity for 5-HT6 over other 5-HT receptors (pKi values are 9.11, 8.81 and 9.02 for human recombinant, native rat and native human 5-HT6 receptors respectively).

Technical Data

M.Wt:
482.81
Formula:
C18H21Cl2N3O4S.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
402713-81-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression.
    Wesolowska and Nikiforuk
    Neuropharmacology, 2007;52:1274
  2. The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats.
    Foley et al.
    Neuropharmacology, 2008;54:1166
  3. SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models.
    Hirst et al.
    Eur.J.Pharm., 2006;553:109

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Citation for SB 399885 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SB 399885 hydrochloride include:

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