SB 399885 hydrochloride

Key Product Details

Product Description

SB 399885 hydrochloride is a potent, brain penetrant, orally active 5-HT₆ antagonist. Displays > 200-fold selectivity for 5-HT₆ over other 5-HT receptors (pK_i values are 9.11, 8.81 and 9.02 for human recombinant, native rat and native human 5-HT₆ receptors respectively).

Product Specifications for SB 399885 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SB 399885 hydrochloride

The following data is based on the product molecular weight 482.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.07 mL	10.36 mL	20.71 mL
5 mM	0.41 mL	2.07 mL	4.14 mL
10 mM	0.21 mL	1.04 mL	2.07 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Foley The selective 5-HT₆ receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats. Neuropharmacology 2008 PMID: 18455201
• Hirst SB-399885 is a potent, selective 5-HT₆ receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. Eur.J.Pharm. 2006 PMID: 1706979
• Wesolowska and Nikiforuk Effects of the brain-penetrant and selective 5-HT₆ receptor antagonist SB-399885 in animal models of anxiety and depression. Neuropharmacology 2007 PMID: 17320917

Product Documents for SB 399885 hydrochloride