Catalog Number: 3189
Chemical Name: N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamide hydrochloride
Biological Activity
Potent, brain penetrant, orally active 5-HT6 antagonist. Displays > 200-fold selectivity for 5-HT6 over other 5-HT receptors (pKi values are 9.11, 8.81 and 9.02� for human recombinant, native rat and native human 5-HT6 receptors respectively).
Technical Data
  • M.Wt:
    482.81
  • Formula:
    C18H21Cl2N3O4S.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    402713-81-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression.
    Wesolowska and Nikiforuk
    Neuropharmacology, 2007;52:1274
  2. The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats.
    Foley et al.
    Neuropharmacology, 2008;54:1166
  3. SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models.
    Hirst et al.
    Eur.J.Pharm., 2006;553:109
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 399885 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Distribution of cells responsive to 5-HT6 receptor antagonist-induced hypophagia.
    Authors: Garfield Et al.
    J Exp Med 2014;266:201

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