Catalog Number: 3810
Chemical Name: N,N'-Dihydroxyoctanediamide
Biological Activity
Histone deacetylase (HDAC) inhibitor (ID50 values are 0.25 and 0.3 μM for HDAC1 and HDAC3 respectively). Potentiates the cytostatic effects of 5-Fluorouracil (Cat. No. 3257) in colorectal cancer cells.
Technical Data
  • M.Wt:
    204.22
  • Formula:
    C8H16N2O4
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Storage:
    Store at +4°C
  • CAS No:
    38937-66-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells.
    Zhang XD, Gillespie SK, Borrow JM, Hersey P.
    Mol Cancer Ther.
  2. Histone hyperacetylation induced by histone deacetylase inhibitors is not sufficient to cause growth inhibition in human dermal fibroblasts.
    Brinkmann et al.
    J.Biol.Chem., 2001;276:22491
  3. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.
    Richon et al.
    Proc.Natl.Acad.Sci.U.S.A, 1998;95:3003

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