5-Fluorouracil

Key Product Details

Product Description

5-Fluorouracil is an anticancer agent. Metabolized to form fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine (FUTP). FdUMP inhibits thymidylate synthase, causing a reduction in dTMP synthesis. FUTP and FdUTP are misincorporated into RNA and DNA respectively.

Product Specifications for 5-Fluorouracil

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 5-Fluorouracil

The following data is based on the product molecular weight 130.08.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	7.69 mL	38.44 mL	76.88 mL
5 mM	1.54 mL	7.69 mL	15.38 mL
10 mM	0.77 mL	3.84 mL	7.69 mL
50 mM	0.15 mL	0.77 mL	1.54 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 35 publications citing the usage of this product.

• Peters Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism. Biochim.Biophys.Acta. 2002 PMID: 12084461
• Longley 5-Fluorouracil: mechanisms of action and clinical strategies. Nat.Rev.Cancer 2003 PMID: 12724731
• Ghoshal and Jacob An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug. Biochem.Pharmacol. 1997 PMID: 9264308

Product Documents for 5-Fluorouracil