Anticancer agent. Metabolized to form fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine (FUTP). FdUMP inhibits thymidylate synthase, causing a reduction in dTMP synthesis. FUTP and FdUTP are misincorporated into RNA and DNA respectively.
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All Tocris products are intended for laboratory research use only.
An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug.
Ghoshal and Jacob
Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism.
Peters et al.
5-Fluorouracil: mechanisms of action and clinical strategies.
Longley et al.
The citations listed below are publications that use Tocris products. Selected citations for 5-Fluorouracil include:
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