5-Fluorouracil

  ( 2 citations )    
Product Datasheet
Catalog Number:3257
Alternate Names:5-FU
Chemical Name:5-Fluoro-2,4-(1H,3H)-pyrimidinedione
Product Details
Citations (2)
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Biological Activity
Anticancer agent. Metabolized to form fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine (FUTP). FdUMP inhibits thymidylate synthase, causing a reduction in dTMP synthesis. FUTP and FdUTP are misincorporated into RNA and DNA respectively.
Technical Data
  • M.Wt:
    130.08
  • Formula:
    C4H3FN2O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    51-21-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for 5-Fluorouracil include:

2 Citations: Showing 1 - 2
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  1. Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line.
    Authors: Fukushima Et al.
    Cancer Sci  2015;106:1000
  2. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
    Authors: Robinson Et al.
    PLoS One  2013;8:e78641

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