5-Fluorouracil
Chemical Name: 5-Fluoro-2,4-(1H,3H)-pyrimidinedione
Purity: ≥99%
Biological Activity
5-Fluorouracil is an anticancer agent. Metabolized to form fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine (FUTP). FdUMP inhibits thymidylate synthase, causing a reduction in dTMP synthesis. FUTP and FdUTP are misincorporated into RNA and DNA respectively.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug.
Ghoshal and Jacob
Biochem.Pharmacol., 1997;53:1569 -
Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism.
Peters et al.
Biochim.Biophys.Acta., 2002;1587:194 -
5-Fluorouracil: mechanisms of action and clinical strategies.
Longley et al.
Nat.Rev.Cancer, 2003;3:330
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Citations for 5-Fluorouracil
The citations listed below are publications that use Tocris products. Selected citations for 5-Fluorouracil include:
2 Citations: Showing 1 - 2
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Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line.
Authors: Fukushima Et al.
Cancer Sci 2015;106:1000
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RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
Authors: Robinson Et al.
PLoS One 2013;8:e78641
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