Chemical Name: 5-Fluoro-2,4-(1H,3H)-pyrimidinedione
Biological ActivityAnticancer agent. Metabolized to form fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine (FUTP). FdUMP inhibits thymidylate synthase, causing a reduction in dTMP synthesis. FUTP and FdUTP are misincorporated into RNA and DNA respectively.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug.
Ghoshal and Jacob
Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism.
Peters et al.
5-Fluorouracil: mechanisms of action and clinical strategies.
Longley et al.
Citations for 5-Fluorouracil
The citations listed below are publications that use Tocris products. Selected citations for 5-Fluorouracil include:
2 Citations: Showing 1 - 2
Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line.
Authors: Fukushima Et al.
Cancer Sci 2015;106:1000
RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
Authors: Robinson Et al.
PLoS One 2013;8:e78641
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