Catalog Number: 2299
Alternate Names: Ecopipam hydrobromide
Chemical Name: (6aS-trans)-11-Chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b]azepin-12-ol hydrobromide
Biological Activity
High affinity dopamine D1/D5 receptor antagonist; displays Ki values of 1.2, 2, 980, 5520, 80 and 731 nM for binding to D1, D5, D2, D4, 5-HT and α2a receptors, respectively.
Technical Data
  • M.Wt:
    394.73
  • Formula:
    C19H20ClNO.HBr
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    1227675-51-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists.
    Wu et al.
    J.Med.Chem., 2005;48:680
  2. A comparison of the effects of the D1 receptor antagonists SCH 23390 and SCH 39166 on suppression of feeding behaviour by the D1 agonist SKF38393.
    Terry and Katz
    Psychopharmacology, 1994;113:328
  3. In vivo binding of SCH 39166: a D-1 selective antagonist.
    McQuade et al.
    J.Pharmacol.Exp.Ther., 1991;257:42
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SCH 39166 hydrobromide include:

2 Citations: Showing 1 - 2
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  1. Attenuated dopaminergic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes.
    Authors: Zheng Et al.
    Nat Commun 2014;306:R138
  2. The dopamine D1 receptor is expressed and facilitates relaxation in airway smooth muscle.
    Authors: Mizuta Et al.
    Am J Physiol Regul Integr Comp Physiol 2013;14:89

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