SCH 39166 hydrobromide

Key Product Details

Product Description

SCH 39166 hydrobromide is a high affinity dopamine D₁/D₅ receptor antagonist; displays K_i values of 1.2, 2, 980, 5520, 80 and 731 nM for binding to D₁, D₅, D₂, D₄, 5-HT and α_2a receptors, respectively.

Product Specifications for SCH 39166 hydrobromide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SCH 39166 hydrobromide

The following data is based on the product molecular weight 394.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.53 mL	12.67 mL	25.33 mL
5 mM	0.51 mL	2.53 mL	5.07 mL
10 mM	0.25 mL	1.27 mL	2.53 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 18 publications citing the usage of this product.

• Terry and Katz A comparison of the effects of the D1 receptor antagonists SCH 23390 and SCH 39166 on suppression of feeding behaviour by the D1 agonist SKF38393. Psychopharmacology 1994 PMID: 7862841
• McQuade In vivo binding of SCH 39166: a D-1 selective antagonist. J.Pharmacol.Exp.Ther. 1991 PMID: 1826927
• Wu DA D₁/D₅ receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D₁/D₅ antagonists. J.Med.Chem. 2005 PMID: 15689153

Product Documents for SCH 39166 hydrobromide