Scrambled version of 10Panx
(Cat. No. 3348), a Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions, inhibits P2X7
-mediated dye uptake, ATP-mediated IL-1β
release and caspase-1 activation without altering membrane current in macrophages in vitro
Panx also blocks activation of NMDA receptor secondary currents (I2nd
) by > 70%.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters.
Wang et al.
Am.J.Physiol.Cell Physiol., 2007;293:C1112
Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus.
Thompson et al.
Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor.
Pelegrin and Surprenant
EMBO J., 2006;25:5071