Home / Gap Channel Blockers / Scrambled 10Panx

Scrambled 10Panx

3708 4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3708/1
Scrambled 10Panx
1 Image
Description: Scrambled version of 10Panx (Cat. No. 3348), Panx-1 mimetic inhibitory peptide
Alternative Names: scPanx
Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Scrambled 10Panx is a scrambled version of 10Panx (Cat. No. 3348), a Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions, inhibits P2X7-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. 10Panx also blocks activation of NMDA receptor secondary currents (I2nd) by > 70%.

Technical Data

M.Wt:
1242.37
Formula:
C58H79N15O16
Sequence:
FSVYWAQADR
Solubility:
Soluble to 0.50 mg/ml in water
Storage:
Store at -20°C
CAS No:
1315378-72-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

COA view current batch
Or select another batch:
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for Scrambled 10Panx

The citations listed below are publications that use Tocris products. Selected citations for Scrambled 10Panx include:

4 Citations: Showing 1 - 4

  1. Enhanced Macrophage Pannexin 1 Expression and Hemichannel Activation Exacerbates Lethal Experimental Sepsis.
    Authors: Chen Et al.
    Sci Rep  2019;9:160
  2. Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation.
    Authors: Hudson Et al.
    J Pharmacol Exp Ther  2019;370:44
  3. Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells.
    Authors: Kleiner Et al.
    Mol Vis  2018;24:647
  4. The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain.
    Authors: Albalawi Et al.
    Front Cell Neurosci  2017;11:227

FAQs

No product specific FAQs exist for this product, however you may

View all Peptide FAQs

Tocris Peptides

10Panx

3348
8 Citations
1 Image

Reviews for Scrambled 10Panx

There are currently no reviews for this product. Be the first to review Scrambled 10Panx and earn rewards!

Have you used Scrambled 10Panx?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.