Biological ActivityScrambled 10Panx is a scrambled version of 10Panx (Cat. No. 3348), a Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions, inhibits P2X7-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. 10Panx also blocks activation of NMDA receptor secondary currents (I2nd) by > 70%.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters.
Wang et al.
Am.J.Physiol.Cell Physiol., 2007;293:C1112
Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus.
Thompson et al.
Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor.
Pelegrin and Surprenant
EMBO J., 2006;25:5071
Citations for Scrambled 10Panx
The citations listed below are publications that use Tocris products. Selected citations for Scrambled 10Panx include:
4 Citations: Showing 1 - 4
Enhanced Macrophage Pannexin 1 Expression and Hemichannel Activation Exacerbates Lethal Experimental Sepsis.
Authors: Chen Et al.
Sci Rep 2019;9:160
Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation.
Authors: Hudson Et al.
J Pharmacol Exp Ther 2019;370:44
Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells.
Authors: Kleiner Et al.
Mol Vis 2018;24:647
The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain.
Authors: Albalawi Et al.
Front Cell Neurosci 2017;11:227
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