Scrambled ¹⁰Panx

Name: Scrambled 10 Panx
Brand: Tocris Bioscience
SKU: 3708

Tocris Bioscience | Catalog # 3708

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Citations (8)

Product Documents

Scrambled version of 10Panx (Cat. No. 3348), Panx-1 mimetic inhibitory peptide

Discontinued Product

3708 has been discontinued. View all Gap Channel Blockers products.

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Scrambled version of 10Panx (Cat. No. 3348), Panx-1 mimetic inhibitory peptide

Alternative Names

^scPanx

View all Gap Channel Blockers »

Product Description

Scrambled ¹⁰Panx is a scrambled version of ¹⁰Panx (Cat. No. 3348), a Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions, inhibits P2X₇-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. ¹⁰Panx also blocks activation of NMDA receptor secondary currents (I_2nd) by > 70%.

Product Specifications for Scrambled ¹⁰Panx

Molecular Weight

1242.37

Formula

C₅₈H₇₉N₁₅O₁₆

Storage

Store at -20°C

CAS Number

1315378-72-3

PubChem ID

90488872

InChI Key

VNQGVHMGXBRHRA-QZHJRRRASA-N

SMILES

[H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 0.5mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

Wang Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am.J.Physiol.Cell Physiol. 2007 PMID: 17652431
Thompson Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science 2008 PMID: 19056988
Pelegrin and Surprenant Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X₇ receptor. EMBO J. 2006 PMID: 17036048

Product Documents for Scrambled ¹⁰Panx

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for Scrambled ¹⁰Panx

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for Scrambled ¹⁰Panx

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