Biological Activity Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Inhibits P2X7-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. Also blocks activation of NMDA receptor secondary currents (I2nd) by > 70%.
Soluble to 1 mg/ml in water
Store at -20°C
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All Tocris products are intended for laboratory research use only.
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