10Panx

Tocris Bioscience | Catalog # 3348

Panx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions
Tocris Bioscience

Key Product Details

Description

Panx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions
View all Gap Channel Blockers »

Product Description

10Panx is a panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Inhibits P2X7-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. Also blocks activation of NMDA receptor secondary currents (I2nd) by > 70%.

Product Specifications for 10Panx

Molecular Weight

1242.37

Formula

C58H79N15O16

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

955091-53-9

PubChem ID

44233736

InChI Key

JCJASTVQGSKHKZ-QZHJRRRASA-N

SMILES

[H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 38 publications citing the usage of this product.

Product Documents for 10Panx

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 10Panx

For research use only

Related Research Areas

Ion Channels and Regulators

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