Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Inhibits P2X7
-mediated dye uptake, ATP-mediated IL-1β
release and caspase-1 activation without altering membrane current in macrophages in vitro
. Also blocks activation of NMDA receptor secondary currents (I2nd
) by > 70%.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Pannexin-1 mediates large pore formation and interleukin-1β; release by the ATP-gated P2X7 receptor.
Pelegrin and Surprenant
EMBO J., 2006;25:5071
Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters.
Wang et al.
Am.J.Physiol.Cell Physiol., 2007;293:C1112
Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus.
Thompson et al.
The citations listed below are publications that use Tocris products. Selected citations for 10Panx include:
Showing Results 1 - 3 of 3