Catalog Number: 3348
Biological Activity
Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Inhibits P2X7-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. Also blocks activation of NMDA receptor secondary currents (I2nd) by > 70%.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:
  • Solubility:
    Soluble to 1 mg/ml in 20mM PBS buffer with gentle warming
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pannexin-1 mediates large pore formation and interleukin-1β; release by the ATP-gated P2X7 receptor.
    Pelegrin and Surprenant
    EMBO J., 2006;25:5071
  2. Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters.
    Wang et al.
    Am.J.Physiol.Cell Physiol., 2007;293:C1112
  3. Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus.
    Thompson et al.
    Science, 2008;322:1555

The citations listed below are publications that use Tocris products. Selected citations for 10Panx include:

Showing Results 1 - 3 of 3

  1. Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells.
    Authors: Kowal Et al.
    Cell Metab
  2. P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2.
    Authors: Adamczyk Et al.
    J Cell Sci
  3. ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation.
    Authors: Manohar Et al.
    J Leukoc Biol
Tocris Peptides
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