Spiperone hydrochloride

  ( 5 citations )    
Product Datasheet
Catalog Number:0995
Chemical Name:8-[4-(4-Fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one hydrochloride
Product Details
Citations (5)
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Reviews
Biological Activity
5-HT2A serotonin and selective D2-like dopamine receptor antagonist (Ki values are 0.06, 0.6, 0.08, ~ 350, ~ 3500 nM for D2, D3, D4, D1 and D5 receptors respectively). Antipsychotic.
Technical Data
  • M.Wt:
    431.94
  • Formula:
    C23H26FN3O2.HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    2022-29-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Spiperone hydrochloride include:

5 Citations: Showing 1 - 5
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  1. Pharmacological analysis of dopamine modulation in the Drosophila melanogaster larval heart.
    Authors: Titlow Et al.
    Physiol Rep  2013;1:e00020
  2. Gene-environment interactions affect long-term depression (LTD) through changes in dopamine receptor affinity in Snap25 deficient mice.
    Authors: Baca Et al.
    Brain Res  2013;1532:85
  3. Dopaminergic agonists that result in ocular growth inhibition also elicit transient increases in choroidal thickness in chicks.
    Authors: Nickla Et al.
    Exp Eye Res  2010;91:715
  4. Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors.
    Authors: Zapata Et al.
    J Biol Chem  2007;282:35842
  5. Dopamine targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin's lymphoma.
    Authors: Meredith Et al.
    Proc Natl Acad Sci U S A  2006;103:13485

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