Chemical Name: 8-[4-(4-Fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one hydrochloride
Biological Activity5-HT2A serotonin and selective D2-like dopamine receptor antagonist (Ki values are 0.06, 0.6, 0.08, ~ 350, ~ 3500 nM for D2, D3, D4, D1 and D5 receptors respectively). Antipsychotic.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin).
Hoyer et al.
DA receptor pharmacology.
Seeman and Van Tol
Trends Pharmacol.Sci., 1994;15:264
Citations for Spiperone hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Spiperone hydrochloride include:
6 Citations: Showing 1 - 6
Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands.
Authors: Walory Et al.
Int J Mol Sci 2018;19
Pharmacological analysis of DA modulation in the Drosophila melanogaster larval heart.
Authors: Titlow Et al.
Physiol Rep 2013;1:e00020
Gene-environment interactions affect long-term depression (LTD) through changes in DA receptor affinity in Snap25 deficient mice.
Authors: Baca Et al.
Brain Res 2013;1532:85
DArgic agonists that result in ocular growth inhibition also elicit transient increases in choroidal thickness in chicks.
Authors: Nickla Et al.
Exp Eye Res 2010;91:715
Regulation of DA transporter function and cell surface expression by D3 DA receptors.
Authors: Zapata Et al.
J Biol Chem 2007;282:35842
DA targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin's lymphoma.
Authors: Meredith Et al.
Proc Natl Acad Sci U S A 2006;103:13485
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