Chemical Name: 2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one
Biological ActivitySR 13800 is a potent MCT1 inhibitor (IC50 = 0.5 nM); blocks proliferation of Raji lymphoma cells in vitro. Also inhibits lactate uptake in breast cancer cells in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Monocarboxylate transporter MCT1 is a target for immunosuppression.
Murray et al.
Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors.
Wang et al.
Citations for SR 13800
The citations listed below are publications that use Tocris products. Selected citations for SR 13800 include:
2 Citations: Showing 1 - 2
AXL Mediates Esophageal Adenocarcinoma Cell Invasion through Regulation of Extracellular Acidification and Lysosome Trafficking.
Authors: Maacha Et al.
The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D.
Authors: Liu Et al.
Cell Metab 2017;26:719
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