Potent, non-peptide CCK1
receptor antagonist that displays > 33-fold selectivity over CCK2
values are 6 and 200 nM respectively). Causes an increase in plasma leptin levels and increases food intake in rats in vivo
Soluble to 50 mM in DMSO
Desiccate at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Contrasting roles of Leu356 in the human CCK1 receptor for antagonist SR 27897 and agonist SR 146131 binding.
Gouldson et al.
Regulation of leptin distribution between plasma and cerebrospinal fluid by cholecystokinin receptors.
Cano et al.
Peripheral biological activity of SR 27897: a new potent non-peptide antagonist of CCKA receptors.
Gully et al.
The citations listed below are publications that use Tocris products. Selected citations for SR 27897 include:
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