SR 49059

  ( 4 citations )    
Product Datasheet
Catalog Number:2310
Alternate Names:Relcovaptan
Chemical Name:(2S)-1-[[(2R,3S)-5-Chloro-3-(2-chlorophenyl)-1-[(3,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-hydroxy-1H-indol-2-yl]carbonyl]-2-pyrrolidinecarboxamide
Product Details
Citations (4)
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Reviews
Biological Activity
Potent and selective non-peptide vasopressin V1A receptor antagonist; devoid of agonist activity. Displays high affinity and efficacy at both rat (Ki = 1.6 nM) and human (Ki = 1.1 - 6.3 nM) V1A receptors. Potently antagonizes arginine vasopressin-induced effects in vitro (IC50 = 3.7 nM for inhibition of human platelet aggregation) and is orally active in vivo.
Technical Data
  • M.Wt:
    620.5
  • Formula:
    C28H27Cl2N3O7S
  • Solubility:
    Soluble to 30 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    150375-75-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SR 49059 include:

4 Citations: Showing 1 - 4
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  1. Water deprivation induces neurovascular and cognitive dysfunction through vasopressin-induced oxidative stress.
    Authors: Faraco Et al.
    Acta Neurochir Suppl  2014;34:852
  2. Arginine vasopressin enhances cell survival via a G protein-coupled receptor kinase 2/β-arrestin1/extracellular-regulated kinase 1/2-dependent pathway in H9c2 cells.
    Authors: Zhu Et al.
    Mol Pharmacol  2013;84:227
  3. Arginine-vasopressin V1a receptor inhibition improves neurologic outcomes following an intracerebral hemorrhagic brain injury.
    Authors: Manaenko Et al.
    Neurochem Int  2011;58:542
  4. Post-treatment with SR49059 improves outcomes following an intracerebral hemorrhagic stroke in mice.
    Authors: Manaenko Et al.
    BMC Neurosci  2011;111:191

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