SR 49059

Key Product Details

Product Description

SR 49059 is a potent and selective non-peptide vasopressin V_1A receptor antagonist; devoid of agonist activity. Displays high affinity and efficacy at both rat (K_i = 1.6 nM) and human (K_i = 1.1 - 6.3 nM) V_1A receptors. Potently antagonizes arginine vasopressin-induced effects in vitro (IC₅₀ = 3.7 nM for inhibition of human platelet aggregation) and is orally active in vivo.

Product Specifications for SR 49059

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SR 49059

The following data is based on the product molecular weight 620.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.3 mM	5.37 mL	26.86 mL	53.72 mL
1.5 mM	1.07 mL	5.37 mL	10.74 mL
3 mM	0.54 mL	2.69 mL	5.37 mL
15 mM	0.11 mL	0.54 mL	1.07 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 42 publications citing the usage of this product.

• Tahtaoui Identification of the binding sites of the SR 49059 nonpeptide antagonist into the V_1a vasopressin receptor using sulfydryl-reactive ligands and cysteine mutants as chemical sensors. J.Biol.Chem. 2003 PMID: 12869559
• Serradeil-Le Gal Binding of [³H]SR 49059, a potent nonpeptide vasopressin V_1a antagonist, to rat and human liver membranes. Biochem.Biophys.Res.Comm.
• Serradeil-Le Gal Biochemical and pharmacological properties of SR 49059, a new, potent, nonpeptide antagonist of rat and human vasopressin V_1a receptors. J.Clin.Invest. 1993 PMID: 8392086

Product Documents for SR 49059