Catalog Number: 3607
Chemical Name: 5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine
Biological Activity
Selective inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 0.7 μM). Inhibits the protein-protein interaction between JNK and JIP (IC50 = 239 nM). Displays selectivity over p38 MAPK and Akt. Restores insulin sensitivity in a mouse model of type-2 diabetes.
Technical Data
  • M.Wt:
    261.3
  • Formula:
    C5H3N5O2S3
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    40045-50-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Design, synthesis and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-jun N-terminal kinase.
    De et al.
    J.Med.Chem., 2009;52:1943
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SU 3327 include:

3 Citations: Showing 1 - 3
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  1. Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury.
    Authors: Jang Et al.
    J Biol Chem 2015;6:552
  2. TNF-α induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways.
    Authors: Lo Et al.
    Acta Pharmacol Sin 2014;35:339
  3. Post-transcriptional regulation of placenta growth factor mRNA by hydrogen peroxide.
    Authors: Shaw and Lloyd
    Redox Biol 2012;84:155

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