Chemical Name: 5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine
Biological ActivitySU 3327 is a selective inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 0.7 μM). Inhibits the protein-protein interaction between JNK and JIP (IC50 = 239 nM). Displays selectivity over p38 MAPK and Akt. Restores insulin sensitivity in a mouse model of type-2 diabetes. Displays antibiotic activity against a range of bacteria including S.aureus, A.baumanni, C.difficile and M.tuberculosis.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Citations for SU 3327
The citations listed below are publications that use Tocris products. Selected citations for SU 3327 include:
3 Citations: Showing 1 - 3
Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury.
Authors: Jang Et al.
J Biol Chem 2015;6:552
TNF-α induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways.
Authors: Lo Et al.
Acta Pharmacol Sin 2014;35:339
Post-transcriptional regulation of placenta growth factor mRNA by hydrogen peroxide.
Authors: Shaw and Lloyd
Redox Biol 2012;84:155
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