Catalog Number: 1156
Biological Activity
Sensory neuropeptide and inflammatory mediator. Exerts excitatory effects on central and peripheral neurons, constricts bronchioles and is involved in pain transmission.
Technical Data
  • M.Wt:
    1347.6
  • Formula:
    C63H98N18O13S
  • Sequence:
    RPKPQQFFGLM

    (Modifications: Met-11 = C-terminal amide)

  • Solubility:
    Soluble to 0.80 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    33507-63-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice.
    Andoh et al.
    J.Pharmacol.Exp.Ther., 1998;286:1140
  3. Substance P.
    Pernow et al.
    Pharmacol.Rev., 1983;35:85
  4. Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators.
    Walsh et al.
    Br.J.Pharmacol., 1995;114:1343

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