Biological ActivitySubstance P is a sensory neuropeptide and inflammatory mediator. Exerts excitatory effects on central and peripheral neurons, constricts bronchioles and is involved in pain transmission.
(Modifications: Met-11 = C-terminal amide)
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Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice.
Andoh et al.
Pernow et al.
Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators.
Walsh et al.
Citations for Substance P
The citations listed below are publications that use Tocris products. Selected citations for Substance P include:
15 Citations: Showing 1 - 10
Neuropeptide-induced modulation of carcinogenesis in a metastatic breast cancer cell line (MDA-MB-231LUC+).
Authors: Gutierrez and Boada
Cancer Cell Int 2019;18:216
Substance P increases CCN2 dependent on TGF-beta yet Collagen Type I via TGF-beta1 dependent and independent pathways in tenocytes.
Authors: Frara Et al.
Connect Tissue Res 2018;59:30
Role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing.
Authors: Kowtharapu Et al.
Int J Mol Sci 2018;19
Endomorphin-2 Inhibition of Substance P Signaling within Lamina I of the Spinal Cord Is Impaired in Diabetic Neuropathic Pain Rats.
Authors: Wan Et al.
Front Mol Neurosci 2017;9:167
Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors.
Mol Biol Cell 2017;28(24):3554
Increased CCN2, substance P and tissue fibrosis are associated with sensorimotor declines in a rat model of repetitive overuse injury.
Authors: Fisher Et al.
J Cell Commun Signal 2015;9:37
μ-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain.
Authors: Chen Et al.
Long-term potentiation of excitatory synaptic strength in spinothalamic tract neurons of the rat spinal cord.
Authors: Hur and Park
Korean J Physiol Pharmacol 2013;17:553
Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries.
Authors: Alsaqati Et al.
Purinergic Signal 2013;10:241
Evidence for regulatory diversity and auto-regulation at the TAC1 locus in sensory neurones.
Authors: Shanley Et al.
J Neurosci 2011;8:10
Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research.
Authors: Robery Et al.
PLoS One 2011;6:e24439
Activation of glycogen synthase kinase-3 β is required for hyperDA and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex.
Authors: Li Et al.
J Neurosci 2009;29:15551
A homogeneous fluorescent live-cell assay for measuring 7-transmembrane receptor activity and agonist functional selectivity through β-arrestin recruitment.
Authors: Hanson Et al.
Antioxid Redox Signal 2009;14:798
Substance P selectively decreases paired pulse depression in the rat hippocampal slice.
Authors: Wease and Davies
BMC Neurosci 2005;6:66
Role of neurokinin 3 receptors in supraoptic vasopressin and oxyt. neurons.
Authors: Howe Et al.
J Biomol Screen 2004;24:10103
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