T 0156 hydrochloride

Key Product Details

Product Description

T 0156 hydrochloride is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5); more selective than sildenafil (IC₅₀ values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). Selective over 30 other enzymes and receptors (IC₅₀ > 10 mM) and potentiates electrical field stimulation-induced relaxation of isolated rabbit corpus cavernosum. Active in vivo.

Licensing Information

Sold with the permission of Tanabe Seiyaku Co. Ltd.

Product Specifications for T 0156 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for T 0156 hydrochloride

The following data is based on the product molecular weight 620.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	6.45 mL	32.25 mL	64.51 mL
1.25 mM	1.29 mL	6.45 mL	12.90 mL
2.5 mM	0.65 mL	3.23 mL	6.45 mL
12.5 mM	0.13 mL	0.65 mL	1.29 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Mochida T-0156, a novel phosphodiesterase type 5 inhibitor, and silde. have different pharmacological effects on penile tumescence and electroretinogram in dogs. Eur.J.Pharmacol. 2004 PMID: 14757152
• Mochida Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor. Eur.J.Pharmacol. 2002 PMID: 12450574

Product Documents for T 0156 hydrochloride