T 0156 hydrochloride
Chemical Name: 1,2-Dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride
Biological ActivityT 0156 hydrochloride is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5); more selective than sildenafil (IC50 values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). Selective over 30 other enzymes and receptors (IC50 > 10 mM) and potentiates electrical field stimulation-induced relaxation of isolated rabbit corpus cavernosum. Active in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor.
Mochida et al.
T-0156, a novel phosphodiesterase type 5 inhibitor, and silde. have different pharmacological effects on penile tumescence and electroretinogram in dogs.
Mochida et al.
Citation for T 0156 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for T 0156 hydrochloride include:
1 Citation: Showing 1 - 1
Melanopsin mediates light-dependent relaxation in blood vessels.
Authors: Sikka Et al.
J Biol Chem 2014;111:17977
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