T 0156 hydrochloride

Catalog # Availability Size / Price Qty
1676/10
1676/50
T 0156 hydrochloride | CAS No. 324572-93-2 | Phosphodiesterase Inhibitors
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Description: Highly potent, selective PDE5 inhibitor

Chemical Name: 1,2-Dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

Potent and selective inhibitor of phosphodiesterase type 5 (PDE5); more selective than sildenafil (IC50 values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). Selective over 30 other enzymes and receptors (IC50 > 10 mM) and potentiates electrical field stimulation-induced relaxation of isolated rabbit corpus cavernosum. Active in vivo.

Technical Data

M.Wt:
620.06
Formula:
C31H29N5O7.HCl
Solubility:
Soluble to 25 mM in ethanol with gentle warming and to 25 mM in DMSO with gentle warming
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
324572-93-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Tanabe Seiyaku Co. Ltd.

Product Datasheets

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Citation for T 0156 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for T 0156 hydrochloride include:

1 Citation: Showing 1 - 1

  1. Melanopsin mediates light-dependent relaxation in blood vessels.
    Authors: Sikka Et al.
    J Biol Chem  2014;111:17977

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