Catalog Number: 3050
Chemical Name: 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-benzenesulfonamide hydrochloride
Biological Activity
Selective α1A-adrenoceptor antagonist (pKi values are 9.97, 9.64 and 8.86 for α1A, α1B and α1D subtypes respectively). Decreases resting maximal urethral pressure with negligable effect on mean arterial blood pressure in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Alpha 1-adrenoceptor subtype selectivity of tamsulosin: studies using livers from different species.
    Garcia-Sainz et al.
    Eur.J.Pharmacol., 1995;289:1
  2. Effects of tamsulosin metabolites at alpha-1 adrenoceptor subtypes.
    Taguchi et al.
    J.Pharmacol.Exp.Ther., 1997;280:1
  3. Effects of tamsulosin on resting urethral pressure and arterial blood pressure in anaesthetized female dogs.
    Ohtake et al.
    J.Pharm.Pharmacol., 2005;58:345

The citations listed below are publications that use Tocris products. Selected citations for Tamsulosin hydrochloride include:

1 Citations: Showing 1 - 1

  1. Hydrogen sulfide causes vanilloid receptor 1-mediated neurogenic inflammation in the airways.
    Authors: Trevisani Et al.
    Br J Pharmacol 2005;145:1123

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