Chemical Name: 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride
Biological ActivityTamsulosin hydrochloride is a selective α1A-adrenoceptor antagonist (pKi values are 9.97, 9.64 and 8.86 for α1A, α1B and α1D subtypes respectively). Decreases resting maximal urethral pressure with negligable effect on mean arterial blood pressure in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Alpha 1-adrenoceptor subtype selectivity of tamsulosin: studies using livers from different species.
Garcia-Sainz et al.
Effects of tamsu. metabolites at alpha-1 adrenoceptor subtypes.
Taguchi et al.
Effects of tamsu. on resting urethral pressure and arterial blood pressure in anaesthetized female dogs.
Ohtake et al.
Citations for Tamsulosin hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Tamsulosin hydrochloride include:
3 Citations: Showing 1 - 3
Acute tobacco smoke exposure exacerbates the inflammatory response to corneal wounds in mice via the sympathetic nervous system.
Authors: Xiao Et al.
Commun Biol 2019;2:33
Inhibition of smooth muscle force generation by focal adhesion kinase inhibitors in the hyperplastic human prostate.
Authors: Kunit Et al.
Am J Physiol Renal Physiol 2014;307:F823
Hydrogen sulfide causes vanilloid receptor 1-mediated neurogenic inflammation in the airways.
Authors: Trevisani Et al.
Br J Pharmacol 2005;145:1123
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