Tasquinimod

Catalog # Availability Size / Price Qty
7051/25
7051/5
Tasquinimod | CAS No. 254964-60-8 | Class II Histone Deacetylases Inhibitors
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Description: High affinity HDAC4 negative allosteric modulator; also binds S100A9; antiangiogenic

Chemical Name: 1,2-dihydro-4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]-3-quinolinecarboxamide

Purity: ≥98%

Product Details
Reviews

Biological Activity

High affinity negative allosteric modulator of HDAC4 (Kd = 10 - 30 nM). Binds the regulatory Zn2+ binding domain of HDAC4. Suppresses hypoxia-induced decrease in histone acetylation in human prostate cancer cells in vitro. Also binds S100A9. Antiangiogenic. Inhibits endothelial sprouting in vitro and growth of prostate tumor xenografts in nude mice. Orally bioavailable.

Technical Data

M.Wt:
406.36
Formula:
C20H17F3N2O4
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
254964-60-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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