TC 14012

Name: TC 14012
Brand: Tocris Bioscience
SKU: 4300

Tocris Bioscience | Catalog # 4300

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Citations (15)

Product Documents

CXCR4 antagonist; ACKR3 (CXCR7) agonist

Discontinued Product

4300 has been discontinued. View all Chemokine Receptor Antagonists products.

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

CXCR4 antagonist; ACKR3 (CXCR7) agonist

View all Chemokine Receptor Antagonists »

Product Description

TC 14012 is a CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC₅₀ = 350 nM for CXCR7).

Product Specifications for TC 14012

Molecular Weight

2066.43

Formula

C₉₀H₁₄₀N₃₄O₁₉S₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

368874-34-4

PubChem ID

90488928

InChI Key

SGDDHDBBOJNZKY-UXNLHULBSA-N

SMILES

[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

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g/mol

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The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

Burger Small peptide inhibitors of the CXCR4 chemokine receptor (CS184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Blood 2005 PMID: 15905192
Gravel The peptidomimetic CXCR4 antagonist TC14012 recruits beta arrestin to CXCR7: roles of receptor domains. J.Biol.Chem. 2010 PMID: 20956518
Tamamura Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives. Org.Biomol.Chem. 2003 PMID: 14649896

Product Documents for TC 14012

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for TC 14012

For research use only

Citations for TC 14012

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