Biological ActivityTC 14012 is a CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC50 = 350 nM for CXCR7).
(Modifications: Disulfide bridge: 4-13, Ala-3 = 3-(2-naphthalenyllalanine), X-6 and X-12 = L-Citrulline, X-8 = D-Citrulline, Arg-14 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives.
Tamamura et al.
Small peptide inhibitors of the CXCR4 chemokine receptor (CS184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells.
Burger et al.
The peptidomimetic CXCR4 antagonist TC14012 recruits beta arrestin to CXCR7: roles of receptor domains.
Gravel et al.
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VersaClone cDNA Plasmids
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