Potent and selective sphingosine-1-phosphate receptor 1 (S1P1
) agonist (EC50
= 35 nM), displays >100-fold selectivity against receptor subtypes S1P2-5
. Induces a dose-dependent reduction in circulating blood lymphocyte counts in rodent models. Orally bioavailable.
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All Tocris products are intended for laboratory research use only.
4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1.
Pennington et al.
ACS Med.Chem.Lett., 2011;2:752