TCN 238

Key Product Details

Product Description

TCN 238 is a positive allosteric modulator of mGlu₄ receptors (EC₅₀ = 1.0 μM for human and rat mGlu₄ receptors). Orally available and brain penetrant.

Product Specifications for TCN 238

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TCN 238

The following data is based on the product molecular weight 197.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.07 mL	25.35 mL	50.70 mL
5 mM	1.01 mL	5.07 mL	10.14 mL
10 mM	0.51 mL	2.53 mL	5.07 mL
50 mM	0.10 mL	0.51 mL	1.01 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

• East An orally bioavailable positive allosteric modulator of the mGlu₄ receptor with efficacy in an animal model of motor dysfunction. Bioorg.Med.Chem.Lett. 2010 PMID: 20638279

Product Documents for TCN 238