Catalog Number: 4259
Chemical Name: (E)-4-(2-Phenylethenyl)-2-pyrimidinamine
Biological Activity
Positive allosteric modulator of mGlu4 receptors (EC50 = 1.0 μM for human and rat mGlu4 receptors). Orally available and brain penetrant.
Technical Data
  • M.Wt:
    197.24
  • Formula:
    C12H11N3
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    125404-04-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction.
    East et al.
    Bioorg.Med.Chem.Lett., 2010;20:4901
Citations:

The citations listed below are publications that use Tocris products. Selected citations for TCN 238 include:

1 Citations: Showing 1 - 1

  1. Subacute activation of mGlu4 receptors causes the feedback inhibition of its gene expression in rat brain.
    Authors: Pershina and Arkhipov
    Life Sci. 2016;153:50

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