Chemical Name: (E)-4-(2-Phenylethenyl)-2-pyrimidinamine
Biological ActivityPositive allosteric modulator of mGlu4 receptors (EC50 = 1.0 μM for human and rat mGlu4 receptors). Orally available and brain penetrant.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction.
East et al.
Citation for TCN 238
The citations listed below are publications that use Tocris products. Selected citations for TCN 238 include:
1 Citation: Showing 1 - 1
Subacute activation of mGlu4 receptors causes the feedback inhibition of its gene expression in rat brain.
Authors: Pershina and Arkhipov
Life Sci. 2016;153:50
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