Chemical Name: 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide
Biological ActivityTCS 5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively). Attenuates diabetic hypersensitivity in an in vivo rat model.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Experiment
Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals.
Wei et al.
Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat.
Wei et al.
Citation for TCS 5861528
The citations listed below are publications that use Tocris products. Selected citations for TCS 5861528 include:
1 Citation: Showing 1 - 1
A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery.
Authors: Ko Et al.
Sci Rep 2019;9:2430
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