Catalog Number: 3938
Chemical Name: 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide
Biological Activity
TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively). Attenuates diabetic hypersensitivity in an in vivo rat model.
Technical Data
  • M.Wt:
    369.42
  • Formula:
    C19H23N5O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    332117-28-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals.
    Wei et al.
    Anesthesiology, 2009;111:147
  2. Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat.
    Wei et al.
    Neuropharmacology., 2010;58:578
  3. Spinal TRPA1 ion channels contribute to the cutaneous neurogenic inflammation in the rat.
    Wei et al.
    Neurosci.Letts., 2010;479:253
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