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TCS 5861528

3938 1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3938/10
3938/50
TCS 5861528 | CAS No. 332117-28-9 | TRPA1 Blockers
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Description: TRPA1 blocker

Chemical Name: 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TCS 5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively). Attenuates diabetic hypersensitivity in an in vivo rat model.

Technical Data

M.Wt:
369.42
Formula:
C19H23N5O3
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
332117-28-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals.
    Wei et al.
    Anesthesiology, 2009;111:147
  2. Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat.
    Wei et al.
    Neuropharmacology., 2010;58:578
  3. Spinal TRPA1 ion channels contribute to the cutaneous neurogenic inflammation in the rat.
    Wei et al.
    Neurosci.Letts., 2010;479:253

Product Datasheets

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Citation for TCS 5861528

The citations listed below are publications that use Tocris products. Selected citations for TCS 5861528 include:

1 Citation: Showing 1 - 1

  1. A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery.
    Authors: Ko Et al.
    Sci Rep  2019;9:2430

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