Home / TRPA1 Blockers / TCS 5861528

TCS 5861528

3938 1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3938/10
3938/50
TRPA1 Blockers Small Molecule
1 Image
Description: TRPA1 blocker

Chemical Name: 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively). Attenuates diabetic hypersensitivity in an in vivo rat model.

Technical Data

M.Wt:
369.42
Formula:
C19H23N5O3
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
332117-28-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals.
    Wei et al.
    Anesthesiology, 2009;111:147
  2. Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat.
    Wei et al.
    Neuropharmacology., 2010;58:578
  3. Spinal TRPA1 ion channels contribute to the cutaneous neurogenic inflammation in the rat.
    Wei et al.
    Neurosci.Letts., 2010;479:253

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citation for TCS 5861528

The citations listed below are publications that use Tocris products. Selected citations for TCS 5861528 include:

1 Citation: Showing 1 - 1

  1. A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery.
    Authors: Ko Et al.
    Sci Rep  2019;9:2430

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for TCS 5861528

There are currently no reviews for this product. Be the first to review TCS 5861528 and earn rewards!

Have you used TCS 5861528?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.