TCS JNK 6o
Chemical Name: N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxybenzeneacetamide
Biological ActivityTCS JNK 6o is an ATP-competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 values are 2, 4 and 52 nM for JNK1, JNK2 and JNK3 respectively). Displays > 1000 fold selectivity over other kinases, including ERK2 and p38. Inhibits c-Jun phosphorylation (EC50 = 920 nM) and prevents collagen-induced platelet aggregation in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.
Szczepankiewicz et al.
Involvement of the mirogen-activated protein kinase c-Jun NH2-terminal kinase 1 in thrombus formation.
Kauskot et al.
Citations for TCS JNK 6o
The citations listed below are publications that use Tocris products. Selected citations for TCS JNK 6o include:
3 Citations: Showing 1 - 3
Targeting JNK pathway promotes human hematopoietic stem cell expansion.
Authors: Xiao Et al.
Cell Discov 2019;5:2
Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection.
Authors: Souvannaseng Et al.
PLoS Pathog 2018;14:e1007418
Establishment of mouse expanded potential stem cells.
Authors: Yang Et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for TCS JNK 6o
There are currently no reviews for this product. Be the first to review TCS JNK 6o and earn rewards!
Have you used TCS JNK 6o?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image