tcY-NH₂

Name: tcY-NH 2
Brand: Tocris Bioscience
SKU: 1488

Tocris Bioscience | Catalog # 1488

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Citations (19)

Product Documents

Selective PAR4 antagonist

Discontinued Product

1488 has been discontinued. View all Protease-Activated Receptor Antagonists products.

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Selective PAR4 antagonist

Alternative Names

(trans-Cinnamoyl)-YPGKF-NH₂

View all Protease-Activated Receptor Antagonists »

Product Description

tcY-NH₂ is a selective PAR₄ antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.

Product Specifications for tcY-NH₂

Molecular Weight

739.87

Formula

C₄₀H₄₉N₇O₇

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

327177-34-4

PubChem ID

11479675

InChI Key

XKRAKQXQVIGYQC-PHOSSJRVSA-N

SMILES

NCCCC[C@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)\C=C\C1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.

Hollenberg and Saifeddine Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides. Can.J.Physiol.Pharmacol. 2001 PMID: 11405248
Ma Thrombin-induced platelet endostatin release is blocked by a proteinase activated receptor-4 (PAR4) antagonist. Br.J.Pharmacol. 2001 PMID: 11606309
Hollenberg Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br.J.Pharmacol. 2004 PMID: 15451771

Product Documents for tcY-NH₂

Certificate of Analysis

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Product Specific Notices for tcY-NH₂

For research use only

Citations for tcY-NH₂

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