Catalog Number: 1488
Alternate Names: (trans-Cinnamoyl)-YPGKF-NH2
Biological Activity
Selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.
Technical Data
  • M.Wt:
    739.87
  • Formula:
    C40H49N7O7
  • Sequence:
    YPGKF

    (Modifications: Tyr-1 = trans-Cinnamoyl-Tyr, Phe-5 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    327177-34-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo.
    Hollenberg et al.
    Br.J.Pharmacol., 2004;143:443
  2. Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides.
    Hollenberg and Saifeddine
    Can.J.Physiol.Pharmacol., 2001;79:439
  3. Thrombin-induced platelet endostatin release is blocked by a proteinase activated receptor-4 (PAR4) antagonist.
    Ma et al.
    Br.J.Pharmacol., 2001;134:701
Citations:

The citations listed below are publications that use Tocris products. Selected citations for tcY-NH2 include:

3 Citations: Showing 1 - 3
Filter your results:

  1. Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4.
    Authors: Wang
    Proc Natl Acad Sci U S A 2017;114(41):10948
  2. Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα.
    Authors: Carrim Et al.
    Br J Cancer 2015;6:640
  3. Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis.
    Authors: Sales Et al.
    Redox Biol 2015;34:346

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