hh Tempol (CAS 2226-96-2): R&D Systems
Catalog Number: 3082
Chemical Name: 1-Oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine
Biological Activity
Superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects.
Technical Data
  • M.Wt:
    172.24
  • Formula:
    C9H18NO2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    2226-96-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The superoxide scavenger TEMPOL induces urokinase receptor (uPAR) expression in human prostate cancer cells.
    Francis and Sehgal
    Mol.Cancer, 2006;5:21
  2. Neuroprotective effect of tempol, a catalytic scavenger of peroxynitrite-derived free radicals, in a mouse traumatic brain injury model.
    Deng-Bryant et al.
    J.Cereb.Blood Flow Metab., 2008;28:1114
  3. TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion.
    Khattab
    EurJ.Pharmacol., 2006;548:167
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Tempol include:

5 Citations: Showing 1 - 5
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  1. Sestrin 2 Regulates PDGF Receptor β (PDGFRβ) Expression by Modulating Proteasomal and Nrf2 Transcription Factor Functions.
    Authors: Tomasovic Et al.
    Brain Res 2015;NULL
  2. p53ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state.
    Authors: Senturk Et al.
    Proc Natl Acad Sci U S A 2014;111:E3287
  3. Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels.
    Authors: Nesuashvili Et al.
    Mol Pharmacol 2013;83:1007
  4. Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18.
    Authors: Valente Et al.
    Am J Physiol Heart Circ Physiol 2012;303:H282
  5. Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation.
    Authors: Ruparel Et al.
    J Biol Chem 2012;153:2031

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