Tempol

Catalog # Availability Size / Price Qty
3082/100
Tempol | CAS No. 2226-96-2 | Additional Antioxidant Compounds
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Description: Superoxide scavenger; antioxidant

Chemical Name: 1-Oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine

Purity: ≥99%

Product Details
Citations (8)
Reviews (1)

Biological Activity

Superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects.

Technical Data

M.Wt:
172.24
Formula:
C9H18NO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
2226-96-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Neuroprotective effect of tempol, a catalytic scavenger of peroxynitrite-derived free radicals, in a mouse traumatic brain injury model.
    Deng-Bryant et al.
    J.Cereb.Blood Flow Metab., 2008;28:1114
  2. TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion.
    Khattab
    EurJ.Pharmacol., 2006;548:167
  3. The superoxide scavenger TEMPOL induces urok. receptor (uPAR) expression in human prostate cancer cells.
    Francis and Sehgal
    Mol.Cancer, 2006;5:21

Product Datasheets

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Citations for Tempol

The citations listed below are publications that use Tocris products. Selected citations for Tempol include:

8 Citations: Showing 1 - 8

  1. Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Mediated Redox Signaling and Vascular Remodeling by 16α-Hydroxyestrone in Human Pulmonary Artery Cells: Implications in Pulmonary Arterial Hypertension.
    Authors: Hood Et al.
    Hypertension  2016;68:796
  2. The Nox1/4 Dual Inhibitor GKT137831 or Nox4 Knockdown Inhibits Angiotensin-II-Induced Adult Mouse Cardiac Fibroblast Proliferation and Migration. AT1 Physically Associates With Nox4.
    Authors: Somanna Et al.
    J Cell Physiol  2016;231:1130
  3. Sestrin 2 Regulates PDGF Receptor β (PDGFRβ) Expression by Modulating Proteasomal and Nrf2 Transcription Factor Functions.
    Authors: Tomasovic Et al.
    Brain Res  2015;NULL
  4. Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related.
    Authors: Beggs Et al.
    Toxicology  2015;331:35
  5. p53ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state.
    Authors: Senturk Et al.
    Proc Natl Acad Sci U S A  2014;111:E3287
  6. Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels.
    Authors: Nesuashvili Et al.
    Mol Pharmacol  2013;83:1007
  7. Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18.
    Authors: Valente Et al.
    Am J Physiol Heart Circ Physiol  2012;303:H282
  8. Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation.
    Authors: Ruparel Et al.
    J Biol Chem  2012;153:2031

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Tempol blunts 15d-PGJ2-induced ROS levels in HL-1 cardiomyocytes
By Chintan Koyani on 10/13/2018
Species: Mouse

HL-1 cardiomyocytes were incubated with Tempol (1 mM) for 30 min prior to 15d-PGJ2 treatments (15 μM) for 1 h to follow ROS generation using carboxy-H2DCFDA (10 μM). Figure shows that the antioxidant Tempol (a cell-permeable superoxide anion scavenger) blunted 15d-PGJ2-induced ROS formation efficiently.

PMID: 24698234

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