Chemical Name: 1-Oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine
Biological ActivityTempol is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Neuroprotective effect of tempol, a catalytic scavenger of peroxynitrite-derived free radicals, in a mouse traumatic brain injury model.
Deng-Bryant et al.
J.Cereb.Blood Flow Metab., 2008;28:1114
TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion.
The superoxide scavenger TEMPOL induces urok. receptor (uPAR) expression in human prostate cancer cells.
Francis and Sehgal
Citations for Tempol
The citations listed below are publications that use Tocris products. Selected citations for Tempol include:
9 Citations: Showing 1 - 9
Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF
Authors: Rastogi Et al.
PLoS Pathog 2021;17:e1009712
Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Mediated Redox Signaling and Vascular Remodeling by 16α-Hydroxyestrone in Human Pulmonary Artery Cells: Implications in Pulmonary Arterial Hypertension.
Authors: Hood Et al.
The Nox1/4 Dual Inhibitor GKT137831 or Nox4 Knockdown Inhibits Angiotensin-II-Induced Adult Mouse Cardiac Fibroblast Proliferation and Migration. AT1 Physically Associates With Nox4.
Authors: Somanna Et al.
J Cell Physiol 2016;231:1130
Sestrin 2 Regulates PDGF Receptor β (PDGFRβ) Expression by Modulating Proteasomal and Nrf2 Transcription Factor Functions.
Authors: Tomasovic Et al.
Brain Res 2015;NULL
Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related.
Authors: Beggs Et al.
p53ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state.
Authors: Senturk Et al.
Proc Natl Acad Sci U S A 2014;111:E3287
Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels.
Authors: Nesuashvili Et al.
Mol Pharmacol 2013;83:1007
Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18.
Authors: Valente Et al.
Am J Physiol Heart Circ Physiol 2012;303:H282
Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation.
Authors: Ruparel Et al.
J Biol Chem 2012;153:2031
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HL-1 cardiomyocytes were incubated with Tempol (1 mM) for 30 min prior to 15d-PGJ2 treatments (15 μM) for 1 h to follow ROS generation using carboxy-H2DCFDA (10 μM). Figure shows that the antioxidant Tempol (a cell-permeable superoxide anion scavenger) blunted 15d-PGJ2-induced ROS formation efficiently.