Teniposide

Key Product Details

Product Description

Teniposide is a DNA topoisomerase II inhibitor and viral transduction enhancer. It induces breaks in double-stranded DNA and prevents DNA repair. Teniposide enhances transduction of recombinant adeno-associated virus 2 (rAAV2) by up to 40-fold in human cells in vitro and by 100-fold in vivo at 24 h post-transduction.

Product Specifications for Teniposide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Teniposide

The following data is based on the product molecular weight 656.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.52 mL	7.61 mL	15.23 mL
5 mM	0.30 mL	1.52 mL	3.05 mL
10 mM	0.15 mL	0.76 mL	1.52 mL
50 mM	0.03 mL	0.15 mL	0.30 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Yusenko A novel cell-based screening assay for small-molecule MYB inhibitors identifies podophyllotoxins teniposide and etoposide as inhibitors of MYB activity. Sci.Rep. 2018 PMID: 30177851
• Nicolson Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens. J.Virol. 2016 PMID: 27147738

Product Documents for Teniposide