Thalidomide 4'-oxyacetamide-PEG2-amine

Tocris Bioscience | Catalog # 6967

Cereblon ligand with PEG linker and terminal amine for onward chemistry
Tocris Bioscience

Key Product Details

Description

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Alternative Names

Thalidomide - linker 14
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Product Description

Thalidomide 4'-oxyacetamide-PEG2-amine is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a PEG linker with ethylamine terminal ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was Thalidomide - linker 14

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PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications for Thalidomide 4'-oxyacetamide-PEG2-amine

Molecular Weight

498.92

Formula

C21H26N4O8.HCl

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

N-[2-[2-(2-Aminoethoxy)ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride

CAS Number

2376990-30-4

SMILES

NCCOCCOCCNC(COC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 24.95 50
DMSO 24.95 50

Preparing Stock Solutions for Thalidomide 4'-oxyacetamide-PEG2-amine

The following data is based on the product molecular weight 498.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.01 mL 20.04 mL 40.09 mL
2.5 mM 0.80 mL 4.01 mL 8.02 mL
5 mM 0.40 mL 2.00 mL 4.01 mL
25 mM 0.08 mL 0.40 mL 0.80 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

There are currently no references for this product.

Product Documents for Thalidomide 4'-oxyacetamide-PEG2-amine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Thalidomide 4'-oxyacetamide-PEG2-amine

For research use only

Citations for Thalidomide 4'-oxyacetamide-PEG2-amine

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