Degrader Building Blocks: Products

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Pomalidomide 4'-PEG2-amine 

Cereblon ligand with PEG linker and terminal amine for onward chemistry

VH 032 amide-PEG3-acid 

VHL ligand with PEG linker and terminal acid for onward chemistry

Pomalidomide 4'-PEG3-acid 

Cereblon ligand with PEG linker and terminal acid for onward chemistry

Pomalidomide 4'-alkylC5-acid 

Cereblon ligand with alkyl linker and terminal acid for onward chemistry

VH 032 amide-PEG4-amine 

VHL ligand with PEG linker and terminal amine for onward chemistry

VH 032 amide-PEG2-amine 

VHL ligand with PEG linker and terminal amine for onward chemistry

Pomalidomide 4'-PEG4-amine 

Cereblon ligand with PEG linker and terminal amine for onward chemistry

VH 032 amide-PEG3-amine 

VHL ligand with PEG linker and terminal amine for onward chemistry

VH 032 amide-alkylC4-amine 

VHL ligand with alkyl linker and terminal amine for onward chemistry

Thalidomide 4'-oxyacetamide-PEG3-amine 

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Thalidomide 4'-oxyacetamide-PEG4-amine 

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Thalidomide 4'-oxyacetamide-alkylC4-amine 

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

(+)-JQ1 PA 

Functionalized BET bromodomain inhibitor; 'click' target ligand for PROTACs

VH 032 amide-alkylC4-acid 

VHL ligand with alkyl linker and terminal acid for onward chemistry

Thalidomide 4'-ether-PEG2-alkyne 

Cereblon ligand with PEG linker and terminal alkyne for onward chemistry

Pomalidomide 4'-alkylC5-amine 

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

VH 032 amide-alkylC10-amine 

VHL ligand with alkyl linker and terminal amine for onward chemistry

VH 032 phenol-alkylC6-amine 

VHL ligand with alkyl linker and terminal amine for onward chemistry

Thalidomide 4'-ether-PEG5-amine 

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Thalidomide 4'-oxyacetamide-alkylC4-azide 

Cereblon ligand with alkyl linker and terminal azide for onward chemistry

VH 032, amine 

Functionalized VHL ligand for PROTACs

TC E3 5031 

Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs

A 410099.1, amine 

Functionalized IAP ligand for PROTACs

A 410099.1 amide-PEG3-amine 

IAP ligand with PEG linker and terminal amine for onward chemistry

A 410099.1 amide-PEG2-amine 

IAP ligand with PEG linker and terminal amine for onward chemistry

A 410099.1 amide-alkylC4-amine 

IAP ligand with alkyl linker and terminal amine for onward chemistry

(+)-JQ1 carboxylic acid 

Carboxylic acid-functionalized BET bromodomain inhibitor; target ligand for PROTACs

Thalidomide 4'-ether-alkylC6-amine 

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

TC E3 5032 

Precursor to Pomalidomide-based PROTACs

VH 032, propargyl 

Alkyne-functionalized VH 032; 'click' VHL ligand for PROTACs

VH 032 amide-PEG2-alkyne 

VHL ligand with PEG linker and terminal alkyne for onward chemistry

Thalidomide, propargyl 

Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs

Thalidomide 4'-ether-alkylC2-amine 

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Pomalidomide 4'-alkylC2-amine 

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

VH 032 amide-alkylC2-amine 

VHL ligand with alkyl linker and terminal amine for onward chemistry

VH 032 amide-alkylC6-amine 

VHL ligand with alkyl linker and terminal amine for onward chemistry

VH 032 amide-PEG1-amine 

VHL ligand with PEG linker and terminal amine for onward chemistry

VH 032 amide-alkylC8-amine 

VHL ligand with alkyl linker and terminal amine for onward chemistry

VH 032 phenol-alkylC4-amine 

VHL ligand with alkyl linker and terminal amine for onward chemistry

VH 032, phenol 

Hydroxyl functionalized VHL ligand

Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine 

Cereblon ligand with alkyl-PEG-alkyl linker and terminal amine for onward chemistry

Thalidomide 4'-ether-alkylC4-amine 

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Pomalidomide 4'-alkylC8-amine 

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Thalidomide 4'-oxyacetamide-alkylC8-amine 

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Thalidomide 4'-oxyacetamide-alkylC2-amine 

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

VH 101, phenol 

Hydroxyl functionalized VHL ligand

Thalidomide 4'-oxyacetamide-PEG1-amine 

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Thalidomide 4'-oxyacetamide-PEG2-amine 

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Thalidomide 4'-oxyacetamide-alkylC6-amine 

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

cis VH 032, amine dihydrochloride 

Negative control for VH 032, amine (Cat. No. 6462)
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