hh Thapsigargin (CAS 67526-95-8): R&D Systems
Catalog Number: 1138
Chemical Name: (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6- (Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate
Biological Activity
Potent inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases. Causes ER stress; can be used to induce autophagy in mammalian cells.
Technical Data
  • M.Wt:
    650.76
  • Formula:
    C34H50O12
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    67526-95-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Kinetics of thapsigargin-Ca2+-ATPase (sarcoplasmic reticulum) interaction reveals a two-step binding mechanism and picomolar inhibition.
    Davidson and Varhol
    J.Biol.Chem., 1995;270:11731
  2. Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival.
    Ding et al.
    J.Biol.Chem., 2007;282:4702
  3. Specific substitutions at amino acid 256 of the sarcoplasmic/endoplasmic reticulum Ca2+ transport ATPase mediate resistance to thapsigargin in thapsigargin-resistant hamster cells.
    Yu et al.
    J.Biol.Chem., 1998;273:3542
  4. A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases.
    Treiman et al.
    TiPS, 1998;19:131
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Thapsigargin include:

26 Citations: Showing 1 - 10
Filter your results:

  1. Swelling-activated Ca2+ channels trigger Ca2+ signals in Merkel cells.
    Authors: Haeberle Et al.
    MBio ;3:e1750
  2. Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity.
    Authors: Mätlik Et al.
    Cell Death Dis 2016;6:e2032
  3. Control of sensory neuron excitability by serotonin involves 5HT2C receptors and Ca2+-activated chloride channels.
    Authors: Salzer Et al.
    Neuropharmacology 2016;110 (A):277
  4. α-1 adrenoreceptors modulate GABA release onto ventral tegmental area dopamine neurons.
    Authors: Velásquez-Martínez Et al.
    Pflugers Arch 2015;88:110
  5. Binding of αherpesvirus Glycoprotein H to Surface α4β1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane.
    Authors: Azab Et al.
    Endocrinology 2015;6
  6. Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion.
    Authors: Cao Et al.
    PLoS One 2015;209:879
  7. Differential regulation of GnRH secretion in the preoptic area (POA) and the median eminence (ME) in male mice.
    Authors: Glanowska and Moenter
    Neuropharmacology 2015;156:231
  8. TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis.
    Authors: Shambharkar Et al.
    J Cell Biol 2015;10:e0127480
  9. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
    Authors: Dobson Et al.
    J Neuroinflammation 2015;10:e0125974
  10. Orai1 and STIM1 mediate SOCE and contribute to apoptotic resistance of pancreatic adenocarcinoma.
    Authors: Kondratska Et al.
    PLoS One 2014;1843:2263
  11. Downregulation of BRCA1 protein in BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation.
    Authors: Podszywalow-Bartnicka Et al.
    Biochim Biophys Acta 2014;13:3727
  12. Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells.
    Authors: Soltoff and Lannon
    PLoS One 2013;8:e72881
  13. Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis.
    Authors: Varadarajan Et al.
    PLoS One 2013;8:e56603
  14. Recruitment of the intracellular Ca2+ by ultrashort electric stimuli: the impact of pulse duration.
    Authors: Semenov Et al.
    Cell Calcium 2013;54:145
  15. The expression and relaxant effect of bitter taste receptors in human bronchi.
    Authors: Grassin-Delyle Et al.
    Respir Res 2013;14:134
  16. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation.
    Authors: Pinheiro Et al.
    Cell Commun Signal 2013;11:70
  17. Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release.
    Authors: Few Et al.
    Proc Natl Acad Sci U S A 2012;109:E452
  18. ER stress induces anabolic resistance in muscle cells through PKB-induced blockade of mTORC1.
    Authors: Deldicque Et al.
    PLoS One 2011;6:e20993
  19. Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.
    Authors: Li and Burrell
    Learn Mem 2011;18:545
  20. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem 2011;116:984
  21. Dysregulation of presynaptic calcium and synaptic plasticity in a mouse model of 22q11 deletion syndrome.
    Authors: Earls Et al.
    PLoS One 2010;30:15843
  22. Plasticity of burst firing induced by synergistic activation of metabotropic glutamate and acetylcholine receptors.
    Authors: Moore Et al.
    Neuron 2009;61:287
  23. Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels.
    Authors: Szikra Et al.
    PLoS One 2009;4:e6723
  24. H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus.
    Authors: Gerich Et al.
    J Neurosci 2009;458:937
  25. Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous γ-aminobutyric acid release onto cerebellum Purkinje neurons.
    Authors: Kelm Et al.
    Cell Cycle 2007;323:356
  26. Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
    Authors: Bender Et al.
    J Neurosci 2006;26:4166
Expand to show all 26 Citations

Have you used Thapsigargin?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information