Potent inhibitor of sarco-endoplasmic reticulum Ca2+
-ATPases. Causes ER stress; can be used to induce autophagy in mammalian cells.
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Kinetics of thapsigargin-Ca2+-ATPase (sarcoplasmic reticulum) interaction reveals a two-step binding mechanism and picomolar inhibition.
Davidson and Varhol
Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival.
Ding et al.
Specific substitutions at amino acid 256 of the sarcoplasmic/endoplasmic reticulum Ca2+ transport ATPase mediate resistance to thapsigargin in thapsigargin-resistant hamster cells.
Yu et al.
A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases.
Treiman et al.
The citations listed below are publications that use Tocris products. Selected citations for Thapsigargin include:
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