Thapsigargin

  ( 26 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1138
Chemical Name:(3S,3aR,4S,6S,6AR,7S,8S,9bS)-6- (Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate
Product Details
Citations (26)
Reviews
Biological Activity
Potent inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases. Causes ER stress; can be used to induce autophagy in mammalian cells.
Technical Data
  • M.Wt:
    650.76
  • Formula:
    C34H50O12
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >97
  • Storage:
    Desiccate at -20°C
  • CAS No:
    67526-95-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Thapsigargin include:

26 Citations: Showing 1 - 10
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  1. Swelling-activated Ca2+ channels trigger Ca2+ signals in Merkel cells.
    Authors: Haeberle Et al.
    MBio  ;3:e1750
  2. Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity.
    Authors: Mätlik Et al.
    Cell Death Dis  2016;6:e2032
  3. Control of sensory neuron excitability by serotonin involves 5HT2C receptors and Ca2+-activated chloride channels.
    Authors: Salzer Et al.
    Neuropharmacology  2016;110 (A):277
  4. α-1 adrenoreceptors modulate GABA release onto ventral tegmental area dopamine neurons.
    Authors: Velásquez-Martínez Et al.
    Pflugers Arch  2015;88:110
  5. Binding of αherpesvirus Glycoprotein H to Surface α4β1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane.
    Authors: Azab Et al.
    Endocrinology  2015;6
  6. Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion.
    Authors: Cao Et al.
    PLoS One  2015;209:879
  7. Differential regulation of GnRH secretion in the preoptic area (POA) and the median eminence (ME) in male mice.
    Authors: Glanowska and Moenter
    Neuropharmacology  2015;156:231
  8. TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis.
    Authors: Shambharkar Et al.
    J Cell Biol  2015;10:e0127480
  9. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
    Authors: Dobson Et al.
    J Neuroinflammation  2015;10:e0125974
  10. Orai1 and STIM1 mediate SOCE and contribute to apoptotic resistance of pancreatic adenocarcinoma.
    Authors: Kondratska Et al.
    PLoS One  2014;1843:2263
  11. Downregulation of BRCA1 protein in BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation.
    Authors: Podszywalow-Bartnicka Et al.
    Biochim Biophys Acta  2014;13:3727
  12. Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells.
    Authors: Soltoff and Lannon
    PLoS One  2013;8:e72881
  13. Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis.
    Authors: Varadarajan Et al.
    PLoS One  2013;8:e56603
  14. Recruitment of the intracellular Ca2+ by ultrashort electric stimuli: the impact of pulse duration.
    Authors: Semenov Et al.
    Cell Calcium  2013;54:145
  15. The expression and relaxant effect of bitter taste receptors in human bronchi.
    Authors: Grassin-Delyle Et al.
    Respir Res  2013;14:134
  16. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation.
    Authors: Pinheiro Et al.
    Cell Commun Signal  2013;11:70
  17. Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release.
    Authors: Few Et al.
    Proc Natl Acad Sci U S A  2012;109:E452
  18. ER stress induces anabolic resistance in muscle cells through PKB-induced blockade of mTORC1.
    Authors: Deldicque Et al.
    PLoS One  2011;6:e20993
  19. Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.
    Authors: Li and Burrell
    Learn Mem  2011;18:545
  20. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem  2011;116:984
  21. Dysregulation of presynaptic calcium and synaptic plasticity in a mouse model of 22q11 deletion syndrome.
    Authors: Earls Et al.
    PLoS One  2010;30:15843
  22. Plasticity of burst firing induced by synergistic activation of metabotropic glutamate and acetylcholine receptors.
    Authors: Moore Et al.
    Neuron  2009;61:287
  23. Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels.
    Authors: Szikra Et al.
    PLoS One  2009;4:e6723
  24. H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus.
    Authors: Gerich Et al.
    J Neurosci  2009;458:937
  25. Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous γ-aminobutyric acid release onto cerebellum Purkinje neurons.
    Authors: Kelm Et al.
    Cell Cycle  2007;323:356
  26. Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
    Authors: Bender Et al.
    J Neurosci  2006;26:4166
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