Potent histamine H3
antagonist/inverse agonist. Ki
values are 25 and 27 nM for human recombinant H3
receptors respectively. Blocks eosinophil shape change (IC50
= 1.4 μ
M) and chemotaxis (IC50
= 519 nM) induced by histamine. Freely crosses the blood-brain barrier. Also available as part of the Histamine H3 Receptor Tocriset™
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Characterization of histamine-H3 receptors in guinea pig ileum with H3-selective ligands.
Hew et al.
Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation.
Ling et al.
Compared pharmacology of human H3 and H4 receptors: structure-activity relationships of histamine derivatives.
Gbahou et al.
Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow.
Liu et al.
Mol. Pharmacol., 2001;59:420
The citations listed below are publications that use Tocris products. Selected citations for Thioperamide include:
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