Thioperamide

  ( 4 citations )    
Product Datasheet
Catalog Number:0644
Chemical Name:N-Cyclohexyl-4-(imidazol-4-yl)-1-piperidinecarbothioamide
Product Details
Citations (4)
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Reviews
Biological Activity
Potent histamine H3 and H4 antagonist/inverse agonist. Ki values are 25 and 27 nM for human recombinant H3 and H4 receptors respectively. Blocks eosinophil shape change (IC50 = 1.4 μM) and chemotaxis (IC50 = 519 nM) induced by histamine. Freely crosses the blood-brain barrier. Also available as part of the Histamine H3 Receptor Tocriset™.
Technical Data
  • M.Wt:
    292.44
  • Formula:
    C15H24N4S
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    106243-16-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Thioperamide include:

4 Citations: Showing 1 - 4
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  1. Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma.
    Authors: Francis Et al.
    Gut  2012;61:753
  2. Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells.
    Authors: Holden Et al.
    Saudi J Biol Sci  2007;152:891
  3. Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype.
    Authors: Takahashi Et al.
    J Clin Invest  2002;110:1791
  4. Activation of the p38 and p42/p44 mitogen-activated protein kinase families by the histamine H(1) receptor in DDT(1)MF-2 cells.
    Authors: Robinson and Dickenson
    Br J Pharmacol  2001;133:1378

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