Catalog Number: 1812
Alternate Names: Ritalin
Chemical Name: Threo-methyl α-Phenyl-2-piperidineacetate hydrochloride
Biological Activity
Psychomotor stimulant. Inhibitor of dopamine and noradrenalin transporters that increases the extracellular concentration of dopamine and noradrenalin. Increases locomotor activity in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Methylphenidate (Ritalin): behavioral studies in the rat.
    Askenasy et al.
    Int.J.Neurosci., 2007;117:757
  2. Methylphenidate: a review of its neuropharmacological, neuropsychological and adverse clinical effects.
    Leonard et al.
    Human Psychopharm., 2004;19:151

The citations listed below are publications that use Tocris products. Selected citations for Threo-methylphenidate hydrochloride include:

Showing Results 1 - 2 of 2

  1. Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics.
    Authors: Poulin Et al.
    Mol Pharmacol
  2. Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish.
    Authors: Parker Et al.
    PLoS One
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