Chemical Name: (3R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid hydrochloride
Biological ActivityTiagabine hydrochloride is a GABA uptake inhibitor (IC50 = 67 nM in vivo). Exhibits high affinity and selectivity for the GAT-1 GABA transporter. Anticonvulsant; also attenuates established dynorphin-induced allodynia in a mouse model after systemic administration.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA updake inhibitors: identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT-3.
Dhar et al.
Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabap. in mouse models of acute, prolonged, and chronic nociception.
Laughlin et al.
The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-butenyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug ca
Andersen et al.
Citation for Tiagabine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Tiagabine hydrochloride include:
1 Citation: Showing 1 - 1
Neonatal brain injury causes cerebellar learning deficits and Purkinje cell dysfunction.
Nature Communications 2018;9(1):3235
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