Tiagabine hydrochloride

Catalog # Availability Size / Price Qty
4256/10
4256/50
GABA Transporter Inhibitors Small Molecule
1 Image
Description: Selective GAT-1 inhibitor; anticonvulsant

Chemical Name: (3R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid hydrochloride

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

GABA uptake inhibitor (IC50 = 67 nM in vivo). Exhibits high affinity and selectivity for the GAT-1 GABA transporter. Anticonvulsant; also attenuates established dynorphin-induced allodynia in a mouse model after systemic administration.

Technical Data

M.Wt:
412.01
Formula:
C20H25NO2S2.HCl
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
145821-59-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Tiagabine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Tiagabine hydrochloride include:

1 Citation: Showing 1 - 1

  1. Neonatal brain injury causes cerebellar learning deficits and Purkinje cell dysfunction.
    Authors: Sathyanesan
    Nature Communications  2018;9(1):3235

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