Catalog Number: 1509
Alternate Names: (E)-2,3',4,5'-tetramethoxystilbene
Chemical Name: 1-[2,(3,5-Dimethoxyphenyl)ethenyl]-2,4-dimethoxybenzene
Biological Activity
Potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC50 = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. Inhibits cancer cell growth in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in ethanol and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis.
    Chun et al.
    Cancer Res., 2001;61:8164
  2. Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors.
    Kim et al.
    J.Med.Chem., 2002;45:160
  3. Resveratrol analog, 3,5,2',4'-tetramethoxy-trans-stilbene, potentiates the inhibition of cell growth and induces apoptosis in human cancer cells.
    Nam et al.
    Arch.Pharm.Res., 2001;24:441
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