TPEN

Tocris Bioscience | Catalog # 4309

Cell-permeable Zn2+ chelator; also inhibits RNA binding protein Lin28
Tocris Bioscience

Key Product Details

Description

Cell-permeable Zn2+ chelator; also inhibits RNA binding protein Lin28
View all Buffers, Chelators and Reagents »

Product Description

TPEN is a heavy metal chelator. Reacts with both Zn-proteome and Zn-metallothionein (MT) in LLC-PK1 cells; acts as an intracellular chelator of proteomic Zn2+. Activity decreases intracellular zinc levels, and induces apoptosis in HeLa and cultured human retinal pigment epithelium (RPE) cells. Also inhibits RNA binding protein Lin28 (IC50 = 2.5 μM). Cell permeable.

Product Specifications for TPEN

Molecular Weight

424.54

Formula

C26H28N6

Storage

Store at +4°C

Purity

≥97% (HPLC)

Chemical Name

N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine

CAS Number

16858-02-9

PubChem ID

5519

InChI Key

CVRXLMUYFMERMJ-UHFFFAOYSA-N

SMILES

N(CC3=CC=CC=N3)(CC4=CC=CC=N4)CCN(CC2=CC=CC=N2)CC1=CC=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.61 25
Ethanol 42.45 100

Preparing Stock Solutions for TPEN

The following data is based on the product molecular weight 424.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.78 mL 23.55 mL
5 mM 0.47 mL 2.36 mL 4.71 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

Product Documents for TPEN

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TPEN

For research use only

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