Chemical Name: N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine
Biological ActivityTPEN is a heavy metal chelator. Reacts with both Zn-proteome and Zn-metallothionein (MT) in LLC-PK1 cells; acts as an intracellular chelator of proteomic Zn2+. Activity decreases intracellular zinc levels, and induces apoptosis in HeLa and cultured human retinal pigment epithelium (RPE) cells. Also inhibits RNA binding protein Lin28 (IC50 = 2.5 μM). Cell permeable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Role of cellular zinc in programmed cell death: temporal relationship between zinc depletion, activation of caspases, and cleavage of Sp family transcription factors.
Chimienti et al.
Zinc binding ligands and cellular zinc trafficking: apo-metallothionein, glutathione, TPEN, proteomic zinc, and Zn-Sp1.
Rana et al.
Validation of TPEN as a zinc chelator in fluorescence probing of calcium in cells with the indicator Fura-2.
Matias et al.
Depletion of intracellular zinc and copper with TPEN results in apoptosis of cultured human retinal pigment epithelial cells.
Hyun et al.
Small-molecule inhibitors disrupt let-7 oligouridylation and release the selective blockade of let-7 processing by LIN28.
Wang et al.
Cell Rep., 2018;23:3091
Citation for TPEN
The citations listed below are publications that use Tocris products. Selected citations for TPEN include:
1 Citation: Showing 1 - 1
Zinc ion flux during mammalian sperm capacitation.
Nat Commun 2018;9(1):2061
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