tri-GalNAc-PEG3-Azide

Tocris Bioscience | Catalog # 8015

Asialoglycoprotein receptor ligands with PEG3 linker and azide group for onward chemistry
Tocris Bioscience

Key Product Details

Description

Asialoglycoprotein receptor ligands with PEG3 linker and azide group for onward chemistry
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Product Description

tri-GalNAc-PEG3-Azide is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; each molecule incorporates three ASGPR ligands with a PEG3 linker and azide group reactive handle ready for conjugation. Upon binding to the ASGPR, tri-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. tri-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.

Product Specifications for tri-GalNAc-PEG3-Azide

Molecular Weight

1644.83

Formula

C70H125N13O31

Storage

Store at -20°C

Purity

≥90% (HPLC)

CAS Number

2925590-71-0

InChI Key

QNGSUVMZQPQMPB-CNCRQLPOSA-N

SMILES

OC[C@H]([C@@H]([C@@H]([C@H]1NC(C)=O)O)O)O[C@H]1OCCCCC(NCCCNC(CCOCC(COCCC(NCCCNC(CCCCO[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2NC(C)=O)O)O)CO)=O)=O)(COCCC(NCCCNC(CCCCO[C@@H]3O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O)O)CO)=O)=O)NC(CCOCCOCCOCCN=[N+]=[N-])=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 5 4

Preparing Stock Solutions for tri-GalNAc-PEG3-Azide

The following data is based on the product molecular weight 1644.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.04 mM 15.20 mL 76.00 mL 151.99 mL
0.2 mM 3.04 mL 15.20 mL 30.40 mL
0.4 mM 1.52 mL 7.60 mL 15.20 mL
2 mM 0.30 mL 1.52 mL 3.04 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for tri-GalNAc-PEG3-Azide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for tri-GalNAc-PEG3-Azide

For research use only

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