Trifluorothymidine
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Description: Thymidylate synthetase inhibitor
Chemical Name: α,α,α-Trifluorothymidine
Purity: ≥98%
Biological Activity
Trifluorothymidine is a nucleoside analog; inhibitor of thymidylate synthase. Incorporation of the triphosphate form into DNA induces DNA fragmentation. Exhibits antitumor activity.Technical Data
M.Wt:
296.2
Formula:
C10H11F3N2O5
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
70-00-8
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Background References
-
Small molecules enhance CRISPR genome editing in pluripotent stem cells.
Yu et al.
Cell Stem Cell, 2015;16:142 -
Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluorothymidine, a novel antitumor nucleoside, in rats.
Okayama et al.
J.Pharmacol.Exp.Ther., 2012;340:457 -
Potentiation of the antitumor activity of α, α, α-trifluorothymidine by the co-administration of an inhibitor of thymidine phosphorylase at a suitable molar ratio in vivo.
Emura et al.
Int.J.Oncol., 2005;27:449
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