Trifluorothymidine

Tocris Bioscience | Catalog # 4460

Thymidylate synthetase inhibitor
Tocris Bioscience
Discontinued Product
4460 has been discontinued. View all Thymidylate Synthetase Inhibitor products.

Key Product Details

Description

Thymidylate synthetase inhibitor
View all Thymidylate Synthetase Inhibitor »

Product Description

Trifluorothymidine is a nucleoside analog; inhibitor of thymidylate synthase. Incorporation of the triphosphate form into DNA induces DNA fragmentation. Exhibits antitumor activity.

Product Specifications for Trifluorothymidine

Molecular Weight

296.20

Formula

C10H11F3N2O5

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

α,α,α-Trifluorothymidine

CAS Number

70-00-8

PubChem ID

6708818

InChI Key

VSQQQLOSPVPRAZ-GFCOJPQKSA-N

SMILES

O=C1C(C(F)(F)F)=CN(C2O[C@H](CO)[C@@H](O)C2)C(N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 14.81 50
DMSO 29.62 100

Preparing Stock Solutions for Trifluorothymidine

The following data is based on the product molecular weight 296.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.38 mL 16.88 mL 33.76 mL
5 mM 0.68 mL 3.38 mL 6.75 mL
10 mM 0.34 mL 1.69 mL 3.38 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

Calculators

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Product Documents for Trifluorothymidine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Trifluorothymidine

For research use only

Customer Reviews for Trifluorothymidine (1)

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  • Anti-tumor activity of Trifluorothymidine was measured
    Name: Anonymous
    Species: Human
    Cell Line/Tissue: HeLa human cervical cancer cell line
    Verified Customer | Posted 12/23/2019
    The rate of tumor growth (IR) inhibition was regarded as a measure of the antitumor efficacy and was calculated using the relative tumor volume (RTV) in the drug-treated groups (T) compared to that in the control group (C) using the following equation: IR (%) = (1 – T/C) × 100.
    The HeLa human cervical cancer cell line was cultured in EMEM medium with 10% FCS. Anti-tumor activity of Trifluorothymidine was measured.
    Trifluorothymidine 4460

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