Catalog Number: 4460
Chemical Name: α,α,α-Trifluorothymidine
Biological Activity
Nucleoside analog; inhibitor of thymidylate synthase. Incorporation of the triphosphate form into DNA induces DNA fragmentation. Exhibits antitumor activity.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluorothymidine, a novel antitumor nucleoside, in rats.
    Okayama et al.
    J.Pharmacol.Exp.Ther., 2012;340:457
  2. Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells.
    Yu et al.
    Cell Stem Cell, 2015;16:142
  3. Potentiation of the antitumor activity of α, α, α-trifluorothymidine by the co-administration of an inhibitor of thymidine phosphorylase at a suitable molar ratio in vivo.
    Emura et al.
    Int.J.Oncol., 2005;27:449
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