Valinomycin

Catalog # Availability Size / Price Qty
3373/10
3373/50
Valinomycin | CAS No. 2001-95-8 | Ionophores
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Description: Selective K+ ionophore

Chemical Name: Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)

Product Details
Citations (3)
Reviews (2)

Biological Activity

Selective K+ ionophore (K0.5 values are 48, 73, 75, 93 and 246 mM for K+, Rb+, Cs+, Na+ and Li+ respectively) that transports K+ across biological and artificial lipid membranes. Inhibits Ca2+-ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro.

Technical Data

M.Wt:
1111.32
Formula:
C54H90N6O18
Solubility:
Soluble to 25 mM in DMSO and to 25 mM in ethanol
Storage:
Desiccate at -20°C
CAS No:
2001-95-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Interaction of valinomycin and monovalent cations with the (Ca2+,Mg2+)-ATPase of skeletal muscle sarcoplasmic reticulum.
    Davidson and Berman
    J.Biol.Chem., 1985;260:7325
  2. Valinomycin-induced apoptosis in Chinese hamster ovary cells.
    Abdalah et al.
    Neurosci.Letts., 2006;405:68
  3. The effects of the ionophore valinomycin on biomimetic solid supported lipid DPPTE/EPC membranes.
    Rose and Jenkins
    Bioelectrochem., 2007;70:387

Product Datasheets

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Citations for Valinomycin

The citations listed below are publications that use Tocris products. Selected citations for Valinomycin include:

3 Citations: Showing 1 - 3

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Reviews for Valinomycin

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The 5,760 bioactive compound library is a collated compound set of approved drugs and biologically active compound
By Anonymous on 02/01/2020
Application: Species: Other

Biologically active compounds that have been documented to interact with awide range of targets including SB-224289 (Cat. # 1221), MG-624 (Cat.# 1356), GVIA (Cat. No. 1085), DPAT hydrobromide (Cat. No. 1080) and valinomycin (VA; Cat. # 3373) were ordered from Tocris Bioscience

PMID: 27183222

Valimomycin was used in oxidative phosphorylation studies
By Jade Smith on 02/05/2019
Application: Species: Human

Valimomycin was used in oxidative phosphorylation studies. Performed well and gives repeatable results.


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