Valinomycin

Catalog # Availability Size / Price Qty
3373/10
3373/50
Cat.No. 3373 - Valinomycin | C54H90N6O18 | CAS No. 2001-95-8
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Description: Selective K+ ionophore

Chemical Name: Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)

Product Details
Citations (1)
Reviews

Biological Activity

Selective K+ ionophore (K0.5 values are 48, 73, 75, 93 and 246 mM for K+, Rb+, Cs+, Na+ and Li+ respectively) that transports K+ across biological and artificial lipid membranes. Inhibits Ca2+-ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro.

Technical Data

M.Wt:
1111.32
Formula:
C54H90N6O18
Solubility:
Soluble to 25 mM in DMSO and to 25 mM in ethanol
Storage:
Desiccate at -20°C
CAS No:
2001-95-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Interaction of valinomycin and monovalent cations with the (Ca2+,Mg2+)-ATPase of skeletal muscle sarcoplasmic reticulum.
    Davidson and Berman
    J.Biol.Chem., 1985;260:7325
  2. Valinomycin-induced apoptosis in Chinese hamster ovary cells.
    Abdalah et al.
    Neurosci.Letts., 2006;405:68
  3. The effects of the ionophore valinomycin on biomimetic solid supported lipid DPPTE/EPC membranes.
    Rose and Jenkins
    Bioelectrochem., 2007;70:387

Product Datasheets

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Citation for Valinomycin

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