Chemical Name: Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)
Biological ActivityValinomycin is a selective K+ ionophore (K0.5 values are 48, 73, 75, 93 and 246 mM for K+, Rb+, Cs+, Na+ and Li+ respectively) that transports K+ across biological and artificial lipid membranes. Inhibits Ca2+-ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Interaction of valinomycin and monovalent cations with the (Ca2+,Mg2+)-ATPase of skeletal muscle sarcoplasmic reticulum.
Davidson and Berman
Valinomycin-induced apoptosis in Chinese hamster ovary cells.
Abdalah et al.
The effects of the ionophore valinomycin on biomimetic solid supported lipid DPPTE/EPC membranes.
Rose and Jenkins
Citations for Valinomycin
The citations listed below are publications that use Tocris products. Selected citations for Valinomycin include:
3 Citations: Showing 1 - 3
A nanoscale, multi-parametric flow cytometry-based platform to study mitochondrial heterogeneity and mitochondrial DNA dynamics.
Authors: MacDonald Et al.
Commun Biol 2019;2:258
The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis.
Authors: Yin Et al.
Nat Commun 2018;9:2815
SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A.
Authors: Cassilly Et al.
J Cancer 2016;11:e0154932
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Reviews for Valinomycin
Average Rating: 4.5 (Based on 2 Reviews)
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Biologically active compounds that have been documented to interact with awide range of targets including SB-224289 (Cat. # 1221), MG-624 (Cat.# 1356), GVIA (Cat. No. 1085), DPAT hydrobromide (Cat. No. 1080) and valinomycin (VA; Cat. # 3373) were ordered from Tocris Bioscience
Valimomycin was used in oxidative phosphorylation studies. Performed well and gives repeatable results.