Vatalanib succinate

Catalog # Availability Size / Price Qty
5680/10
5680/50
Cat.No. 5680 - Vatalanib succinate | C20H15ClN4.C4H6O4 | CAS No. 212142-18-2
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Description: Potent VEGFR inhibitor; also aromatase inhibitor
Alternative Names: CGP 79787D, PTK787/ZK222584

Chemical Name: N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine succinate

Purity: ≥99%

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Biological Activity

Potent VEGFR inhibitor (IC50 values are 37 and 77 nM for VEGFR-2 and -1, respectively). Inhibits proliferation, migration and survival of HUVECs in vitro and inhibits growth, vascularization and metastasis of tumors expressing VEGFR in mouse models. Also inhibits PDGFR-β, c-Kit and c-Fms. Potent aromatase inhibitor (IC50 = 50 nM). Orally available.

Technical Data

M.Wt:
464.9
Formula:
C20H15ClN4.C4H6O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
212142-18-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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