Vatalanib succinate

   
Product Datasheet
Catalog Number:5680
Alternate Names:CGP 79787D, PTK787/ZK222584
Chemical Name:N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine succinate
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Biological Activity
Potent VEGFR inhibitor (IC50 values are 37 and 77 nM for VEGFR-2 and -1, respectively). Inhibits proliferation, migration and survival of HUVECs in vitro and inhibits growth, vascularization and metastasis of tumors expressing VEGFR in mouse models. Also inhibits PDGFR-β, c-Kit and c-Fms. Potent aromatase inhibitor (IC50 = 50 nM). Orally available.
Technical Data
  • M.Wt:
    464.9
  • Formula:
    C20H15ClN4.C4H6O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    212142-18-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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VersaClone cDNA Plasmids
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Mouse VEGF R3/Flt-4 (NP_032055) VersaClone cDNA

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