VU 0364439

Key Product Details

Product Description

VU 0364439 is a positive allosteric modulator (PAM) of mGlu₄ receptors (EC₅₀ = 19.8 nM in vitro for human mGlu₄).

Product Specifications for VU 0364439

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VU 0364439

The following data is based on the product molecular weight 422.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.84 mL	23.68 mL
5 mM	0.47 mL	2.37 mL	4.74 mL
10 mM	0.24 mL	1.18 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Robichaud Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics. ACS Chem.Neurosci.
• Engers Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu₄ positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS). Bioorg.Med.Chem.Lett. 2010 PMID: 20667732

Product Documents for VU 0364439