VU 0364770

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4469/10
4469/50
VU 0364770 | CAS No. 61350-00-3 | Group III mGluR Modulators
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Description: Positive allosteric modulator of mGlu4 receptors

Chemical Name: N-(3-Chlorophenyl)-2-pyridinecarboxamide

Purity: ≥99%

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Biological Activity

Positive allosteric modulator at mGlu4 receptors (EC50 = 290 nM in mGlu4-expressing HEK 293 cells). Reverses haloperidol-induced catalepsy in rats; prevents attentional deficit and forelimb asymmetry in a rodent model of Parkinson's disease. Exhibits affinity for MAO-B and MAO-A (Ki values are 0.72 μM and 8.5 μM respectively). Brain penetrant.

Technical Data

M.Wt:
232.67
Formula:
C12H9ClN2O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
61350-00-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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