Chemical Name: 2-Chloro-3-(4-methyl-1-piperazinyl)quinoxaline
Biological Activity High affinity 5-HT3 receptor antagonist (IC50 values are 0.04 and 22 nM for human 5HT3A and 5-HT3AB receptors respectively). Exhibits partial agonist activity at 5-HT3A receptors at higher concentrations (EC50 = 5.2 μM). Also histamine H4 receptor antagonist (pKi = 6.64 in HEK cells).
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at RT
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