Catalog Number: 4532
Chemical Name: 2-Chloro-3-(4-methyl-1-piperazinyl)quinoxaline
Biological Activity
High affinity 5-HT3 receptor antagonist (IC50 values are 0.04 and 22 nM for human 5HT3A and 5-HT3AB receptors respectively). Exhibits partial agonist activity at 5-HT3A receptors at higher concentrations (EC50 = 5.2 μM). Also histamine H4 receptor antagonist (pKi = 6.64 in HEK cells).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. VUF10166, a novel compound with differing activities at 5-HT3A and 5-HT3AB receptors.
    Thompson et al.
    J.Pharmacol.Exp.Ther., 2012;341:350
  2. Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo.
    Smits et al.
    J.Med.Chem., 2008;51:2457
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