High affinity 5-HT3
receptor antagonist (IC50
values are 0.04 and 22 nM for human 5HT3A
receptors respectively). Exhibits partial agonist activity at 5-HT3A
receptors at higher concentrations (EC50
= 5.2 μ
M). Also histamine H4
receptor antagonist (pKi
= 6.64 in HEK cells).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
VUF10166, a novel compound with differing activities at 5-HT3A and 5-HT3AB receptors.
Thompson et al.
Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo.
Smits et al.