Chemical Name: 2-Chloro-3-(4-methyl-1-piperazinyl)quinoxaline
Biological ActivityHigh affinity 5-HT3 receptor antagonist (IC50 values are 0.04 and 22 nM for human 5HT3A and 5-HT3AB receptors respectively). Exhibits partial agonist activity at 5-HT3A receptors at higher concentrations (EC50 = 5.2 μM). Also histamine H4 receptor antagonist (pKi = 6.64 in HEK cells).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
VUF10166, a novel compound with differing activities at 5-HT3A and 5-HT3AB receptors.
Thompson et al.
Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo.
Smits et al.
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VersaClone cDNA Plasmids
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