WR 1065 dihydrochloride
Chemical Name: 2-[(3-Aminopropyl)amino]ethanethiol dihydrochloride
Biological ActivityCell-permeable reactive oxygen species scavenger that activates p53 through a JNK-dependent signaling pathway. Activates p21waf-1 and MDM2, represses transcription of Myc and thymidine kinase, and inhibits DNA topoisomerase IIα. Induces cell cycle arrest and exhibits cytoprotective activity towards normal cells but not cancer cells in vivo. Also exhibits broad spectrum antiviral activity in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway.
North et al.
The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase.
Pluquet et al.
WR1065 mitigates AZT-ddl-induced mutagenesis and inhibits viral replication.
Walker et al.
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