Chemical Name: N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine
Biological ActivityPotent chemokine receptor type 4 (CXCR4) antagonist (EC50 = 0.3 nM). Inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cAMP in vitro (EC50 = 1.2 nM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of small molecule CXCR4 antagonists.
Zhan et al.
Pyridinium N-(2'-azinyl)aminides: regioselective synthesis of N-(2-pyridyl) substituted polyamines.
Reyes et al.
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VersaClone cDNA Plasmids
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