WZ 811

Key Product Details

Product Description

WZ 811 is a potent chemokine receptor type 4 (CXCR4) antagonist (EC₅₀ = 0.3 nM). Inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cAMP in vitro (EC₅₀ = 1.2 nM).

Product Specifications for WZ 811

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for WZ 811

The following data is based on the product molecular weight 290.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	13.78 mL	68.88 mL	137.76 mL
1.25 mM	2.76 mL	13.78 mL	27.55 mL
2.5 mM	1.38 mL	6.89 mL	13.78 mL
12.5 mM	0.28 mL	1.38 mL	2.76 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Reyes Pyridinium N-(2'-azinyl)aminides: regioselective synthesis of N-(2-pyridyl) substituted polyamines. Chem.Inform.
• Zhan Discovery of small molecule CXCR4 antagonists. J.Med.Chem. 2007 PMID: 17958344

Product Documents for WZ 811