XAP 044

Tocris Bioscience | Catalog # 5248

Potent and selective mGlu7 antagonist
Tocris Bioscience

Key Product Details

Description

Potent and selective mGlu7 antagonist
View all Group III mGluR Antagonists »

Product Description

XAP 044 is a potent and selective mGlu7 antagonist (IC50 = 88 nM); inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. Displays no effects on the LTP of mGlu7 deficient mice. Exhibits novel activity by binding to the mGlu7 Venus flytrap domain (VFTD). Exhibits anti-anxiety effects in rodent models. Brain penetrant.

Product Specifications for XAP 044

Molecular Weight

380.13

Formula

C15H9IO4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one

CAS Number

196928-50-4

PubChem ID

5428913

InChI Key

XXZKJJYWINSUMJ-UHFFFAOYSA-N

SMILES

OC1=CC=C(C(C(OC3=CC=C(I)C=C3)=CO2)=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.01 100
Ethanol 7.6 20

Preparing Stock Solutions for XAP 044

The following data is based on the product molecular weight 380.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.63 mL 13.15 mL 26.31 mL
5 mM 0.53 mL 2.63 mL 5.26 mL
10 mM 0.26 mL 1.32 mL 2.63 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for XAP 044

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for XAP 044

For research use only

Customer Reviews for XAP 044 (1)

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  • XAP044 successfully antagonize the effect of L-AP4- stimulated mGlu7 receptors
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HEK293 cells
    Verified Customer | Posted 01/05/2018
    We have studied the cross-talk between mGlu7 and alpha1-adrenergic receptor in recombinant HEK293 cells and XAP 044 was successfully used to antagonize the effect of L-AP4. Briefly, after transfection, we measured the modulation of L-AP4, the mGlu7 receptor agonist on phenylephrine-induced stimulation of inositol phosphates formation. The effect of L-AP4 was antagonised by XAP044 (at 10 and 100 micromolar)
    XAP 044 5248

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