Potent and selective mGlu7
= 88 nM); inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. Displays no effects on the LTP of mGlu7
deficient mice. Exhibits novel activity by binding to the mGlu7
Venus flytrap domain (VFTD). Exhibits anti-anxiety effects in rodent models. Brain penetrant.
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Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior.
Gee et al.