antagonist/inverse agonist (IC50
= ~400 nM). Displays no antagonist activity at ERRγ
at concentrations below 10 μ
M. Interferes with PPARγ
-dependent signaling: inhibits PGC-1α
induction of ERRα
and MAO-B gene expression and downregulates the constitutive transcriptional activity of ERRα
in numerous cell lines.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Peroxisome proliferator-activated receptor γ coactivator-1α enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase.
Kong et al.
Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-α inverse agonist XCT790.
Lanvin et al.
Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor alpha (ERRα) ligand.
Willy et al.
The citations listed below are publications that use Tocris products. Selected citations for XCT 790 include:
Showing Results 1 - 2 of 2