XCT 790

Key Product Details

Product Description

XCT 790 is a selective ERRα inverse agonist (IC₅₀ = ~400 nM). Displays no antagonist activity at ERRγ or ERα at concentrations below 10 μM. Interferes with PPARγ coactivator-1α (PGC-1α)/ERRα-dependent signaling: inhibits PGC-1α induction of ERRα and MAO-B gene expression and downregulates the constitutive transcriptional activity of ERRα in numerous cell lines.

Product Specifications for XCT 790

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for XCT 790

The following data is based on the product molecular weight 596.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.77 mL	83.83 mL	167.67 mL
0.5 mM	3.35 mL	16.77 mL	33.53 mL
1 mM	1.68 mL	8.38 mL	16.77 mL
5 mM	0.34 mL	1.68 mL	3.35 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

• Theodoris Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease. Science. 2021 PMID: 33303684
• Kong Peroxisome proliferator-activated receptor γ coactivator-1α enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase. Mol.Pharmacol. 2009 PMID: 19602572
• Willy Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor alpha (ERRα) ligand. Proc.Natl.Acad.Sci.USA
• Lanvin Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-α inverse agonist XCT790. J.Biol.Chem. 2007 PMID: 17631492

Product Documents for XCT 790