XCT 790

Catalog # Availability Size / Price Qty
3928/10
3928/50
Estrogen and Related Receptor Inverse Agonists Small Molecule
1 Image
Description: Selective ERRα inverse agonist

Chemical Name: 3-[4-(2,4-Bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)acrylamide

Purity: ≥99%

Product Details
Citations (2)
Reviews

Biological Activity

Selective ERRα inverse agonist (IC50 = ~400 nM). Displays no antagonist activity at ERRγ or ERα at concentrations below 10 μM. Interferes with PPARγ coactivator-1α (PGC-1α)/ERRα-dependent signaling: inhibits PGC-1α induction of ERRα and MAO-B gene expression and downregulates the constitutive transcriptional activity of ERRα in numerous cell lines.

Technical Data

M.Wt:
596.42
Formula:
C23H13F9N4O3S
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
725247-18-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-α inverse agonist XCT790.
    Lanvin et al.
    J.Biol.Chem., 2007;282:28328
  2. Peroxisome proliferator-activated receptor γ coactivator-1α enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase.
    Kong et al.
    Mol.Pharmacol., 2009;76:854
  3. Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor alpha (ERRα) ligand.
    Willy et al.
    Proc.Natl.Acad.Sci.USA, 2004;101:8912

Product Datasheets

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Citations for XCT 790

The citations listed below are publications that use Tocris products. Selected citations for XCT 790 include:

2 Citations: Showing 1 - 2

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