Catalog Number: 3928
Chemical Name: 3-[4-(2,4-Bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)acrylamide
Biological Activity
Selective ERRα antagonist/inverse agonist (IC50 = ~400 nM). Displays no antagonist activity at ERRγ or ERα at concentrations below 10 μM. Interferes with PPARγ coactivator-1α (PGC-1α)/ERRα-dependent signaling: inhibits PGC-1α induction of ERRα and MAO-B gene expression and downregulates the constitutive transcriptional activity of ERRα in numerous cell lines.
Technical Data
  • M.Wt:
    596.42
  • Formula:
    C23H13F9N4O3S
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    725247-18-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Peroxisome proliferator-activated receptor γ coactivator-1α enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase.
    Kong et al.
    Mol.Pharmacol., 2009;76:854
  2. Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-α inverse agonist XCT790.
    Lanvin et al.
    J.Biol.Chem., 2007;282:28328
  3. Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor alpha (ERRα) ligand.
    Willy et al.
    Proc.Natl.Acad.Sci.USA, 2004;101:8912
Citations:

The citations listed below are publications that use Tocris products. Selected citations for XCT 790 include:

2 Citations: Showing 1 - 2
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  1. Development of a stable cell line with an intact PGC-1α/ERRα axis for screening environmental chemicals.
    Authors: Teng Et al.
    Mol Cancer 2014;444:177
  2. Estrogen-related receptor α is required for efficient human cytomegalovirus replication.
    Authors: Hwang Et al.
    Proc Natl Acad Sci U S A 2014;111:E5706

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