Chemical Name: 3-[4-(2,4-Bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)acrylamide
Biological ActivitySelective ERRα inverse agonist (IC50 = ~400 nM). Displays no antagonist activity at ERRγ or ERα at concentrations below 10 μM. Interferes with PPARγ coactivator-1α (PGC-1α)/ERRα-dependent signaling: inhibits PGC-1α induction of ERRα and MAO-B gene expression and downregulates the constitutive transcriptional activity of ERRα in numerous cell lines.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-α inverse agonist XCT790.
Lanvin et al.
Peroxisome proliferator-activated receptor γ coactivator-1α enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase.
Kong et al.
Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor alpha (ERRα) ligand.
Willy et al.
Citations for XCT 790
The citations listed below are publications that use Tocris products. Selected citations for XCT 790 include:
2 Citations: Showing 1 - 2
Development of a stable cell line with an intact PGC-1α/ERRα axis for screening environmental chemicals.
Authors: Teng Et al.
Mol Cancer 2014;444:177
Estrogen-related receptor α is required for efficient human cytomegalovirus replication.
Authors: Hwang Et al.
Proc Natl Acad Sci U S A 2014;111:E5706
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